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dc.contributor.authorPapadopoulos, Nikolaos G.
dc.contributor.authorCzarlewski, Wienczyslawa
dc.contributor.authorZuberbier, Torsten
dc.contributor.authorMullol, Joaquim
dc.contributor.authorBlain, Hubert
dc.contributor.authorCristol, Jean-Paul
dc.contributor.authorAkdis, Cezmi A.
dc.contributor.authorCanonica, G. Walter
dc.contributor.authorCruz, Alvaro A.
dc.contributor.authorFiocchi, Alessandro
dc.contributor.authorFonseca, Joao A.
dc.contributor.authorFonseca, Susana
dc.contributor.authorGEMİCİOĞLU, Bilun
dc.contributor.authorHaahtela, Tari
dc.contributor.authorIaccarino, Guido
dc.contributor.authorIvancevich, Juan Carlos
dc.contributor.authorJutel, Marek
dc.contributor.authorKlimek, Ludger
dc.contributor.authorKraxner, Helga
dc.contributor.authorKuna, Piotr
dc.contributor.authorLarenas-Linnemann, Desiree E.
dc.contributor.authorMartineau, Adrian
dc.contributor.authorMelen, Erik
dc.contributor.authorOkamoto, Yoshitaka
dc.contributor.authorBousquet, Jean
dc.contributor.authorPfaar, Oliver
dc.contributor.authorRegateiro, Frederico S.
dc.contributor.authorReynes, Jacques
dc.contributor.authorRolland, Yves
dc.contributor.authorRouadi, Philip W.
dc.contributor.authorSamolinski, Boleslaw
dc.contributor.authorSheikh, Aziz
dc.contributor.authorToppila-Salmi, Sanna
dc.contributor.authorValiulis, Arunas
dc.contributor.authorChoi, Hak-Jong
dc.contributor.authorKim, Hyun Ju
dc.contributor.authorAnto, Josep M.
dc.contributor.authorDe la Torre, Rafael
dc.contributor.authorLozano, Nieves Pizarro
dc.contributor.authorLe Moing, Vincent
dc.contributor.authorBedbrook, Anna
dc.contributor.authorAgache, Ioana
dc.date.accessioned2021-03-07T01:41:19Z
dc.date.available2021-03-07T01:41:19Z
dc.identifier.citationBousquet J., Czarlewski W., Zuberbier T., Mullol J., Blain H., Cristol J., De la Torre R., Lozano N. P. , Le Moing V., Bedbrook A., et al., "Potential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2021
dc.identifier.issn1018-2438
dc.identifier.othervv_1032021
dc.identifier.otherav_773ad35a-62ff-48d0-89a2-19c0288fa35b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/167411
dc.identifier.urihttps://doi.org/10.1159/000514204
dc.description.abstractIn this article, we propose that differences in COVID-19 morbidity may be associated with transient receptor potential ankyrin 1 (TRPA1) and/or transient receptor potential vanilloid 1 (TRPV1) activation as well as desensitization. TRPA1 and TRPV1 induce inflammation and play a key role in the physiology of almost all organs. They may augment sensory or vagal nerve discharges to evoke pain and several symptoms of COVID-19, including cough, nasal obstruction, vomiting, diarrhea, and, at least partly, sudden and severe loss of smell and taste. TRPA1 can be activated by reactive oxygen species and may therefore be up-regulated in COVID-19. TRPA1 and TRPV1 channels can be activated by pungent compounds including many nuclear factor (erythroid-derived 2) (Nrf2)-interacting foods leading to channel desensitization. Interactions between Nrf2-associated nutrients and TRPA1/TRPV1 may be partly responsible for the severity of some of the COVID-19 symptoms. The regulation by Nrf2 of TRPA1/TRPV1 is still unclear, but suggested from very limited clinical evidence. In COVID-19, it is proposed that rapid desensitization of TRAP1/TRPV1 by some ingredients in foods could reduce symptom severity and provide new therapeutic strategies.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectGeneral Immunology and Microbiology
dc.subjectImmunology
dc.subjectImmunology and Allergy
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectALERJİ
dc.titlePotential Interplay between Nrf2, TRPA1, and TRPV1 in Nutrients for the Control of COVID-19
dc.typeMakale
dc.relation.journalINTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
dc.contributor.departmentFree University of Berlin , ,
dc.contributor.firstauthorID2528232


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