dc.contributor.author | Inanc, Murat | |
dc.contributor.author | DALKILIC, Eyüp | |
dc.contributor.author | ELBIR, Y. | |
dc.contributor.author | DIRESKENELI, H. | |
dc.contributor.author | KAMALI, Sevil | |
dc.contributor.author | INANC, N. | |
dc.contributor.author | KASAPOGLU-GUNAL, E. | |
dc.date.accessioned | 2021-03-06T21:20:20Z | |
dc.date.available | 2021-03-06T21:20:20Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | INANC N., DALKILIC E., KAMALI S., KASAPOGLU-GUNAL E., ELBIR Y., DIRESKENELI H., Inanc M., "Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis", CLINICAL RHEUMATOLOGY, cilt.26, ss.17-23, 2007 | |
dc.identifier.issn | 0770-3198 | |
dc.identifier.other | av_fe4669ea-3750-4e8f-a571-321172fc379a | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/166288 | |
dc.identifier.uri | https://doi.org/10.1007/s10067-006-0214-5 | |
dc.description.abstract | Our aim is to assess the prevalence and associated clinical features of anti-CCP (cyclic citrullinated peptide) antibodies for RF (rheumatoid factor)-positive and RF-negative rheumatoid arthritis (RA) and psoriatic arthritis (PsA). In a prospective, cross-sectional, multi-centre study, we determined the titres of anti-CCP antibodies in 208 RA patients (129 RF-positive, 79 RF-negative), 56 PsA patients and 39 healthy controls (HC). Clinical parameters including disease activity (disease activity score 28-DAS28), physical disability (health assessment questionnaire-HAQ), functional capacity (functional class) and radiological erosions were investigated in patients with RA. In PsA patients, clinical and radiological features were determined. Anti-CCP2 antibodies were measured using a second-generation anti-CCP enzyme-linked immunosorbent assay (Euro-Diagnostica, Netherlands). One-hundred four of 129 RF-positive RA (81%), 16 of 79 RF-negative RA (20%), seven of 56 PsA patients (12.5%) and none of the HC had anti-CCP antibodies. RA patients with anti-CCP antibodies had significantly higher disease activity, greater loss of function and more frequent erosive disease than anti-CCP antibody-negative group. In subgroup analysis, anti-CCP antibodies in RF-negative patients were also associated with erosive disease. All PsA patients with anti-CCP antibodies had symmetric arthritis with higher number of swollen joints. The prevalence of anti-CCP antibodies in RF-positive RA patients was significantly higher than in RF-negative RA and PsA patients. Anti-CCP antibodies were also associated with erosive disease in RF-negative RA patients. Both anti-CCP and RF tests were negative in 30% of the patients. Anti-CCP positivity was a frequent finding in PsA and associated with symmetrical polyarthritis. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | İmmünoloji ve Romatoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ROMATOLOJİ | |
dc.title | Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis | |
dc.type | Makale | |
dc.relation.journal | CLINICAL RHEUMATOLOGY | |
dc.contributor.department | Marmara Üniversitesi , , | |
dc.identifier.volume | 26 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 17 | |
dc.identifier.endpage | 23 | |
dc.contributor.firstauthorID | 34368 | |