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dc.contributor.authorGlazer, Chad
dc.contributor.authorPADHYA, Tapan
dc.contributor.authorPhelan, Joan
dc.contributor.authorSpivakovsky, Silvia
dc.contributor.authorBOWNE, Helen Yoo
dc.contributor.authorGoldberg, Judith D.
dc.contributor.authorRolnitzky, Linda
dc.contributor.authorRobbins, Miriam
dc.contributor.authorKerr, A. Ross
dc.contributor.authorSirois, David
dc.contributor.authorCalifano, Joseph A.
dc.contributor.authorDemokan, Semra
dc.contributor.authorPattani, Kavita Malhotra
dc.contributor.authorZhang, Zhe
dc.contributor.authorLoyo, Myriam
dc.contributor.authorGoodman, Steven
dc.contributor.authorSidransky, David
dc.contributor.authorBERMUDEZ, Francisco
dc.contributor.authorJEAN-CHARLES, Germain
dc.contributor.authorMCCAFFREY, Thomas
dc.date.accessioned2021-03-06T21:15:24Z
dc.date.available2021-03-06T21:15:24Z
dc.date.issued2010
dc.identifier.citationPattani K. M. , Zhang Z., Demokan S., Glazer C., Loyo M., Goodman S., Sidransky D., BERMUDEZ F., JEAN-CHARLES G., MCCAFFREY T., et al., "Endothelin Receptor Type B Gene Promoter Hypermethylation in Salivary Rinses Is Independently Associated with Risk of Oral Cavity Cancer and Premalignancy", CANCER PREVENTION RESEARCH, cilt.3, ss.1093-1103, 2010
dc.identifier.issn1940-6207
dc.identifier.otherav_fde51b13-0ac0-4d60-a82e-bdf26cc5a029
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/166077
dc.identifier.urihttps://doi.org/10.1158/1940-6207.capr-10-0115
dc.description.abstractEndothelin receptor type B (EDNRB) and kinesin family member 1A (KIF1A) are candidate tumor suppressor genes that are inactivated in cancers. In this study, we evaluated the promoter hypermethylation of EDNRB and KIF1A and their potential use for risk classification in prospectively collected salivary rinses from patients with premalignant/malignant oral cavity lesions. Quantitative methylation-specific PCR was performed to analyze the methylation status of EDNRB and KIF1A in salivary rinses of 191 patients. We proceeded to determine the association of methylation status with histologic diagnosis and estimate classification accuracy. On univariate analysis, diagnosis of dysplasia/cancer was associated with age and KIF1A or EDNRB methylation. Methylation of EDNRB highly correlated with that of KIF1A (P < 0.0001). On multivariable modeling, histologic diagnosis was independently associated with EDNRB (P = 0.0003) or KIF1A (P = 0.027) methylation. A subset of patients analyzed (n = 161) without prior biopsy-proven malignancy received clinical risk classification based on examination. On univariate analysis, EDNRB and risk classification were associated with diagnosis of dysplasia/cancer and remained significant on multivariate analysis (EDNRB: P = 0.047, risk classification: P = 0.008). Clinical risk classification identified dysplasia/cancer with a sensitivity of 71% and a specificity of 58%. The sensitivity of clinical risk classification combined with EDNRB methylation improved to 75%. EDNRB methylation in salivary rinses was independently associated with histologic diagnosis of premalignancy and malignancy and may have potential in classifying patients at risk for oral premalignant and malignant lesions in settings without access to a skilled dental practitioner. This may also potentially identify patients with premalignant and malignant lesions that do not meet the criteria for high clinical risk based on skilled dental examination. Cancer Prev Res; 3(9); 1093-103. (C) 2010 AACR.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectOnkoloji
dc.titleEndothelin Receptor Type B Gene Promoter Hypermethylation in Salivary Rinses Is Independently Associated with Risk of Oral Cavity Cancer and Premalignancy
dc.typeMakale
dc.relation.journalCANCER PREVENTION RESEARCH
dc.contributor.departmentJohns Hopkins University , ,
dc.identifier.volume3
dc.identifier.issue9
dc.identifier.startpage1093
dc.identifier.endpage1103
dc.contributor.firstauthorID85214


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