dc.contributor.author | Susleyici-Duman, Belgin | |
dc.contributor.author | Cagatay, PENBE | |
dc.contributor.author | Ciftci, Cavlan | |
dc.date.accessioned | 2021-03-06T21:11:02Z | |
dc.date.available | 2021-03-06T21:11:02Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Cagatay P., Susleyici-Duman B., Ciftci C., "Lipoprotein lipase gene PvuII polymorphism serum lipids and risk for coronary artery disease: Meta-analysis", DISEASE MARKERS, cilt.23, ss.161-166, 2007 | |
dc.identifier.issn | 0278-0240 | |
dc.identifier.other | av_fd95ed8d-a9f4-41d6-9576-834dd8002b39 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/165889 | |
dc.identifier.uri | https://doi.org/10.1155/2007/863712 | |
dc.description.abstract | Our aim was to determine whether lipoprotein lipase gene PvuII polymorphism can be considered as an independent risk factor for coronary artery disease (CAD) by conducting a meta-analysis of all available published trials, including our own study. In 7 seperate studies, 3289 subjects were screened for this substitution; meta-analysis included only some of these individuals. Among the 7 studies, 6 were performed on white subjects, whereas I was on patients with Saudi Arabic descent. Subgroup analysis indicated that individuals with PvuII substitution does not have an increased risk for CAD. The LPL-PvuII genotype and allele frequency distributions did not differ significantly between CAD patients and healthy controls. There was no difference in the distribution of LPL-PvuII genotypes between the healthy subjects and the patients with CAD. However, no significant differences in lipid variables (triglyceride and HDL-cholesterol) were determined for the PvuII polymorphisms in the patients with CAD. No significant differences were found in serum triglyceride and HDL-cholesterol levels for LPL-PvuII genotypes when the control and CAD groups were pooled. In conclusion, LPL-PvuII polymorphism cannot be used as independent genetic risk factor for CAD. | |
dc.language.iso | eng | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Patoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyoteknoloji | |
dc.subject | Temel Bilimler | |
dc.subject | Tıp | |
dc.subject | BİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ | |
dc.subject | Mikrobiyoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | GENETİK VE HAYAT | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | PATOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıbbi Genetik | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.title | Lipoprotein lipase gene PvuII polymorphism serum lipids and risk for coronary artery disease: Meta-analysis | |
dc.type | Makale | |
dc.relation.journal | DISEASE MARKERS | |
dc.contributor.department | Marmara Üniversitesi , , | |
dc.identifier.volume | 23 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 161 | |
dc.identifier.endpage | 166 | |
dc.contributor.firstauthorID | 28980 | |