dc.contributor.author | Sismanoglu, A | |
dc.contributor.author | Ilvan, S | |
dc.contributor.author | Durmusoglu, F | |
dc.contributor.author | Kavak, ZN | |
dc.contributor.author | Eren, F | |
dc.contributor.author | Gokasalan, H | |
dc.contributor.author | Turkeri, L | |
dc.date.accessioned | 2021-03-06T20:32:07Z | |
dc.date.available | 2021-03-06T20:32:07Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Gokasalan H., Turkeri L., Kavak Z., Eren F., Sismanoglu A., Ilvan S., Durmusoglu F., "Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors", GYNECOLOGIC AND OBSTETRIC INVESTIGATION, cilt.59, ss.36-40, 2005 | |
dc.identifier.issn | 0378-7346 | |
dc.identifier.other | av_faa5445c-5098-4f2d-ab06-c4daf111ddbd | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/164104 | |
dc.identifier.uri | https://doi.org/10.1159/000080933 | |
dc.description.abstract | Background/Aim: To investigate the expression and value for diagnosis of the genes, p53 and pTEN, the protein, Ki-67, and the receptors, estrogen and progesterone, in differentiating smooth muscle tumors of the uterus. Material and Method: Seventeen samples of leiomyosarcoma, 2 smooth muscle tumors with uncertain malignant potential ( STUMP), 9 atypical myomas and 15 leiomyomas were stained immunohistochemically. The chi(2) test was used for the statistical analysis of the data. Results: The malignant side of the spectrum was strongly stained for Ki-67 and p53 while uniformly decreasing toward the benign tumors. The results were found to be statistically significant ( p < 0.0001). The staining for progesterone receptor was also statistically significant, but the tumors that were considered benign, such as leiomyoma and atypical myoma, were the ones strongly stained ( p = 0.005). The expression of estrogen receptor was significant in these tumors, but the p value was very close to the cut-off value ( p = 0.07). As the degree of differentiation of the tumor increased, the trend showed stronger staining for estrogen receptor. However, no difference was detected in the staining properties of the tumors for pTEN ( p = 0.2457). Conclusion: The expression of Ki-67, p53 and progesterone receptors is promising in immunodifferentiation of smooth muscle tumors of the uterus with malignant potential. Copyright (C) 2005 S. Karger AG, Basel. | |
dc.language.iso | eng | |
dc.subject | Kadın Hastalıkları ve Doğum | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | KADIN HASTALIKLARI & DOĞUM | |
dc.title | Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors | |
dc.type | Makale | |
dc.relation.journal | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | |
dc.contributor.department | , , | |
dc.identifier.volume | 59 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 36 | |
dc.identifier.endpage | 40 | |
dc.contributor.firstauthorID | 174039 | |