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dc.contributor.authorHart, Ian
dc.contributor.authorTuzum, Erdem
dc.contributor.authorVINCENT, A
dc.contributor.authorMADDISON, P
dc.contributor.authorNewsom-Davis, J
dc.contributor.authorBUCKLEY, C
dc.contributor.authorCLOVER, L
dc.date.accessioned2021-03-06T20:25:50Z
dc.date.available2021-03-06T20:25:50Z
dc.identifier.citationNewsom-Davis J., BUCKLEY C., CLOVER L., Hart I., MADDISON P., Tuzum E., VINCENT A., "Autoimmune disorders of neuronal potassium channels", MYASTHENIA GRAVIS AND RELATED DISORDERS, cilt.998, ss.202-210, 2003
dc.identifier.issn0077-8923
dc.identifier.othervv_1032021
dc.identifier.otherav_fa27d117-24ab-43cf-b937-d8ea200d0d5a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/163793
dc.identifier.urihttps://doi.org/10.1196/annals.1254.022
dc.description.abstractAntibodies to voltage-gated potassium channels (VGKCs) appear likely to be the effector mechanisms in many patients with acquired peripheral nerve hyperexcitability (APNH) syndromes, a group of disorders that include neuromyotonia, cramp-fasciculation syndrome, and Isaacs' syndrome. They may contribute to the associated autonomic changes. Through a central action, they may also be the effector mechanism in those with Morvan's syndrome and in some patients with limbic encephalitis. Evidence supporting this hypothesis includes the increased association of APNH with autoimmune diseases (in particular, myasthenia gravis and thymoma), the response to plasmapheresis, passive transfer of APNH to experimental animals by patients' plasma or immunoglobulins, the action of their serum on VGKC currents studied in vitro, and the presence in many patients of IgG antibodies to VGKCs.
dc.language.isoeng
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectİmmünoloji
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.titleAutoimmune disorders of neuronal potassium channels
dc.typeMakale
dc.relation.journalMYASTHENIA GRAVIS AND RELATED DISORDERS
dc.contributor.department, ,
dc.identifier.volume998
dc.identifier.startpage202
dc.identifier.endpage210
dc.contributor.firstauthorID1998


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