dc.contributor.author | ŞANLI, Yasemin | |
dc.contributor.author | Sanli, Oner | |
dc.contributor.author | Engin, Muge Nur | |
dc.contributor.author | ERDEM, Selçuk | |
dc.contributor.author | Simsek, Duygu Has | |
dc.date.accessioned | 2021-03-02T23:02:06Z | |
dc.date.available | 2021-03-02T23:02:06Z | |
dc.identifier.citation | Simsek D. H. , ŞANLI Y., Engin M. N. , ERDEM S., Sanli O., "Detection of metastases in newly diagnosed prostate cancer by using 68Ga-PSMA PET/CT and its relationship with modified D'Amico risk classification", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020 | |
dc.identifier.issn | 1619-7070 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_1013e3fb-253d-4008-be1e-62a68ea66edf | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/16324 | |
dc.identifier.uri | https://doi.org/10.1007/s00259-020-04995-5 | |
dc.description.abstract | Purpose We aimed to investigate the diagnostic power of 68Ga-PSMA PET/CT in the detection of metastatic spread of newly diagnosed PCa, and evaluate the relationship with modified D'Amico risk classification. Methods We evaluated newly diagnosed PCa patients who underwent 68Ga-PSMA PET/CT prior to therapy. All images were interpreted retrospectively and areas of abnormally increased tracer uptake were documented according to PSMA-RADS version 1.0 system. Patients were divided into risk groups as low, intermediate, or high risk, according to a modification in D'Amico classification system as ISUP grade 3 tumors were included to high-risk group. 68Ga-PSMA PET/CT findings were compared among risk groups as well as PSA levels, clinical T stages, and ISUP grades. Results A total of 356 patients were included to the study with a median PSA level was 16.42 (1.29-7013) ng/ml and median Gleason score was 8 (range: 6-10). Of these, 13(3.7%), 54 (15.1%), and 289 (81.2%) were in the low-, intermediate-, and high-risk groups, respectively. Lymph node metastases were detected in 125 (35.1%) patients, and in 48 of them, metastasis was limited to pelvic lymph nodes (PLN). Sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were calculated as 71.4%, 100%, 95.9%, 100%, and 95.4%, respectively for the detection of PLN, based on histopathological results of 49 patients. Overall, any metastasis was detected in 47.7% of high-risk patients, while only PLN metastases were defined in 3.7% intermediate-risk patients and none of low-risk patients had any kind of metastasis. Conclusion This study revealed that 68Ga-PSMA PET/CT should be routinely used in newly diagnosed high-risk PCa patients; whereas it seems to be of limited use for intermediate-risk group and useless for the low-risk group. | |
dc.language.iso | eng | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Nükleer Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | RADYOLOJİ, NÜKLEER TIP ve MEDİKAL GÖRÜNTÜLEME | |
dc.title | Detection of metastases in newly diagnosed prostate cancer by using 68Ga-PSMA PET/CT and its relationship with modified D'Amico risk classification | |
dc.type | Makale | |
dc.relation.journal | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.contributor.firstauthorID | 2219438 | |