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APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI

dc.contributor.authorFISHER, DK
dc.contributor.authorMISKI, M
dc.contributor.authorGILLUM, AM
dc.contributor.authorMILLER, RW
dc.contributor.authorHIGGINS, TJ
dc.contributor.authorSHEN, X
dc.contributor.authorCOOPER, R
dc.date.accessioned2021-03-06T12:54:49Z
dc.date.available2021-03-06T12:54:49Z
dc.date.issued1995
dc.identifier.citationMISKI M., SHEN X., COOPER R., GILLUM A., FISHER D., MILLER R., HIGGINS T., "APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.5, ss.1519-1522, 1995
dc.identifier.issn0960-894X
dc.identifier.othervv_1032021
dc.identifier.otherav_f6243ce7-c484-4a5e-a7f3-7121b49b65cc
dc.identifier.urihttp://hdl.handle.net/20.500.12627/161275
dc.identifier.urihttps://doi.org/10.1016/0960-894x(95)00250-w
dc.description.abstractUsing a high throughput colorimetric bioassay three aporphine alkaloids, annonaine, nornuciferine and roemerine, were isolated and identified as the CD45 protein tyrosine phosphatase inhibitor metabolites of Rollinia ulei. The nor-aporphine alkaloids, anonaine (1) and nornuciferine (3), exhibited more potent inhibitory activity than that of the N-methylated alkaloid roemerin (2).
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectKİMYA, ORGANİK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleAPORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI
dc.typeMakale
dc.relation.journalBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.contributor.department, ,
dc.identifier.volume5
dc.identifier.issue14
dc.identifier.startpage1519
dc.identifier.endpage1522
dc.contributor.firstauthorID93819


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