dc.contributor.author | ALATLI, C | |
dc.contributor.author | Yazici, Hülya | |
dc.contributor.author | ALTUN, M | |
dc.contributor.author | DALAY, N | |
dc.contributor.author | DOGAN, O | |
dc.date.accessioned | 2021-03-06T12:52:51Z | |
dc.date.available | 2021-03-06T12:52:51Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Yazici H., ALTUN M., ALATLI C., DOGAN O., DALAY N., "c-erbB-2 gene amplification in nasopharyngeal carcinoma", CANCER INVESTIGATION, cilt.18, ss.6-10, 2000 | |
dc.identifier.issn | 0735-7907 | |
dc.identifier.other | av_f6010591-7cdd-4a21-9448-461126661953 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/161201 | |
dc.identifier.uri | https://doi.org/10.3109/07357900009023056 | |
dc.description.abstract | Amplification of the c-erbB-2 gene has been associated with poor prognosis in different types of cancer. However, there are no data an the c-erbB-2 expression levels in nasopharyngeal cancer. In this study, amplification of the gene has been investigated in the tumor tissue of patients with nasopharyngeal cancer by competitive polymerase chain reaction c-ErbB-2 amplification was observed in 43.3% of the patients. The increase in the gene copy number correlated with the T stage. No correlation was found with lymph node involvement, histologic grade, differentiation, presence of metastases, or age and sex. We conclude that c-erbB-2 amplification may contribute to the pathogenesis of nasopharyngeal cancer. Our report is the first study investigating the expression of the c-erbB-2 gene in nasopharyngeal cancer at the DNA level. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Onkoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | c-erbB-2 gene amplification in nasopharyngeal carcinoma | |
dc.type | Makale | |
dc.relation.journal | CANCER INVESTIGATION | |
dc.contributor.department | , , | |
dc.identifier.volume | 18 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 6 | |
dc.identifier.endpage | 10 | |
dc.contributor.firstauthorID | 57130 | |