dc.contributor.author | REMMERS, Elaine F. | |
dc.contributor.author | TAKEUCHI, Masaki | |
dc.contributor.author | MIZUKI, Nobuhisa | |
dc.contributor.author | MEGURO, Akira | |
dc.contributor.author | OMBRELLO, Michael J. | |
dc.contributor.author | KIRINO, Yohei | |
dc.contributor.author | SATORIUS, Colleen | |
dc.contributor.author | GADINA, Massimo | |
dc.contributor.author | Oliveira, Sofia A. | |
dc.contributor.author | KASTNER, Daniel L. | |
dc.contributor.author | Gül, Ahmet | |
dc.contributor.author | Seyahi, Emire | |
dc.contributor.author | LE, Julie | |
dc.contributor.author | BLAKE, Mary | |
dc.contributor.author | ERER, Burak | |
dc.contributor.author | KAWAGOE, Tatsukata | |
dc.contributor.author | Ustek, Duran | |
dc.contributor.author | Tugal-Tutkun, Ilknur | |
dc.contributor.author | Ozyazgan, Yilmaz | |
dc.contributor.author | Sousa, Ines | |
dc.contributor.author | DAVATCHI, Fereydoun | |
dc.contributor.author | Francisco, Vania | |
dc.contributor.author | SHAHRAM, Farhad | |
dc.contributor.author | ABDOLLAHI, Bahar Sadeghi | |
dc.contributor.author | NADJI, Abdolhadi | |
dc.contributor.author | SHAFIEE, Niloofar Mojarad | |
dc.contributor.author | GHADERIBARMI, Fahmida | |
dc.contributor.author | Ohno, Shigeaki | |
dc.contributor.author | UEDA, Atsuhisa | |
dc.contributor.author | ISHIGATSUBO, Yoshiaki | |
dc.date.accessioned | 2021-03-02T22:58:30Z | |
dc.date.available | 2021-03-02T22:58:30Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | TAKEUCHI M., MIZUKI N., MEGURO A., OMBRELLO M. J. , KIRINO Y., SATORIUS C., LE J., BLAKE M., ERER B., KAWAGOE T., et al., "Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility", NATURE GENETICS, cilt.49, sa.3, ss.438-443, 2017 | |
dc.identifier.issn | 1061-4036 | |
dc.identifier.other | av_0fb853ce-ec6f-4a25-ae23-18d895bc764a | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/16105 | |
dc.identifier.uri | https://doi.org/10.1038/ng.3786 | |
dc.description.abstract | We analyzed 1,900 Turkish Behcet's disease cases and 1,779 controls genotyped with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for HLA-B*51. In the Turkish discovery set, we identified three new risk loci, IL1A-IL18, IRF8, and CEBPB-PTPN1, with genomewide significance (P < 5 x 10(-8)) by direct genotyping and ADO-EGR2 by imputation. We replicated the ADO-EGR2, IRF8, and CEBPB-PTPN1 loci by genotyping 969 Iranian cases and 826 controls. Imputed data in 608 Japanese cases and 737 controls further replicated ADO-EGR2 and IRF8, and meta analysis additionally identified R1PK2 and LACC1. The disease associated allele of rs4402765, the lead marker at 11.1A-ILIB, was associated with both decreased IL-1 alpha and increased IL-1 beta production. ABO non-secretor genotypes for two ancestry specific FUT2 SNPs showed strong disease association (P = 5.89 x 10(-15)). Our findings extend the list of susceptibility genes shared with Crohn's disease and leprosy and implicate mucosal factors and the innate immune response to microbial exposure in Behcet's disease susceptibility. | |
dc.language.iso | eng | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıbbi Genetik | |
dc.subject | GENETİK VE HAYAT | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Tıp | |
dc.title | Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behcet's disease susceptibility | |
dc.type | Makale | |
dc.relation.journal | NATURE GENETICS | |
dc.contributor.department | National Institutes of Health (NIH) - USA , , | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 438 | |
dc.identifier.endpage | 443 | |
dc.contributor.firstauthorID | 51219 | |