Neurological aspects of tuberous sclerosis in relation to MRI/MR spectroscopy findings in children with epilepsy

Abstract

Our aim was to evaluate the relationship between the neurological outcome of tuberous sclerosis complex ( TSC) and the findings obtained from both cranial magnetic resonance imaging ( MRI) and single voxel proton spectroscopy ( SVPS). MRIs of 13 children who met the diagnostic criteria for TSC were taken. Eleven of these children also underwent a prospective analysis of SVPS. Fisher's exact test and Mann-Whitney U test were used, where applicable, to detect any signs of the imaging data that would indicate poor outcome, or in other words, poor seizure control and/or high degree of mental retardation.