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dc.contributor.authorDurmaz, Oezlem
dc.contributor.authorGokce, Selim
dc.contributor.authorSokucu, Semra
dc.contributor.authorCeltik, Coskun
dc.contributor.authorGulluoglu, Mine
dc.contributor.authorAydogan, Aysen
dc.date.accessioned2021-03-06T12:35:37Z
dc.date.available2021-03-06T12:35:37Z
dc.date.issued2010
dc.identifier.citationGokce S., Durmaz O., Celtik C., Aydogan A., Gulluoglu M., Sokucu S., "Valproic Acid-Associated Vanishing Bile Duct Syndrome", JOURNAL OF CHILD NEUROLOGY, cilt.25, ss.909-911, 2010
dc.identifier.issn0883-0738
dc.identifier.otherav_f4911908-0eaf-4e3c-8ee2-6aa1f6c1b7a0
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/160323
dc.identifier.urihttps://doi.org/10.1177/0883073809343474
dc.description.abstractHepatotoxicity as a result of valproic acid therapy is well documented. Elevation in aminotransferase activities is rarely associated with symptoms. It sometimes manifests as acute liver failure. Here, we report a 8-year-old girl who was referred for unresolving jaundice and itching for 3 months. Past history revealed afebrile convulsion 5 months previously and beginning of valproic acid treatment. Valproic acid was discontinued after the development of jaundice. Physical examination revealed ichterus, xanthomas on extensor surfaces of extremities, and hepatomegaly without any sign of chronic liver disease. Total and direct bilirubin levels were 20.2 and 12.9 mg/dL, respectively. Enzyme activities indicating cholestasis were increased together with blood cholesterol. Tests for infectious and autoimmune, metabolic, and genetic disorders were not informative. Liver biopsy revealed portal inflammation, severe bile duct loss, and cholestasis. The patient was considered to have valproic acid-associated vanishing bile duct syndrome, which has not been reported previously.
dc.language.isoeng
dc.subjectNöroloji
dc.subjectTıp
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectPEDİATRİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleValproic Acid-Associated Vanishing Bile Duct Syndrome
dc.typeMakale
dc.relation.journalJOURNAL OF CHILD NEUROLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume25
dc.identifier.issue7
dc.identifier.startpage909
dc.identifier.endpage911
dc.contributor.firstauthorID196450


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