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dc.contributor.authorWUHL, Elke
dc.contributor.authorTESTA, Sara
dc.contributor.authorMEHLS, Otto
dc.contributor.authorSCHAEFER, Franz
dc.contributor.authorQaliskan, Salim
dc.contributor.authorCHINALI, Marcello
dc.contributor.authorDE SIMONE, Giovanni
dc.contributor.authorMATTEUCCI, Maria Chiara
dc.contributor.authorPICCA, Stefano
dc.contributor.authorMASTROSTEFANO, Antonio
dc.contributor.authorANARAT, Ali
dc.contributor.authorJECK, Nikola
dc.contributor.authorNEUHAUS, Thomas J.
dc.contributor.authorPECO-ANTIC, Amira
dc.contributor.authorPERUZZI, Licia
dc.date.accessioned2021-03-06T12:13:03Z
dc.date.available2021-03-06T12:13:03Z
dc.date.issued2007
dc.identifier.citationCHINALI M., DE SIMONE G., MATTEUCCI M. C. , PICCA S., MASTROSTEFANO A., ANARAT A., Qaliskan S., JECK N., NEUHAUS T. J. , PECO-ANTIC A., et al., "Reduced Systolic myocardial chronic renal insufficiency", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, cilt.18, ss.593-598, 2007
dc.identifier.issn1046-6673
dc.identifier.othervv_1032021
dc.identifier.otherav_f2dd12e4-35c2-4d88-92ce-ddd3b682580f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/159264
dc.identifier.urihttps://doi.org/10.1681/asn.2006070691
dc.description.abstractIncreased left ventricular (LV) mass in children with chronic renal insufficiency (CRI) might be adaptive to sustain myocardial performance in the presence of increased loading conditions. It was hypothesized that in children with CRI, LV systolic function is impaired despite increased LV mass (LVM). Standard echocardiograms were obtained in 130 predialysis children who were aged 3 to 18 yr (59% boys) and had stages II through IV chronic kidney disease and in 130 healthy children of similar age, gender distribution, and body build. Systolic function was assessed by measurement of fractional shortening at the endocardial (eS) and midwall (mS) levels and computation of end-systolic stress (myocardial afterload). The patients with CRI exhibited a 6% lower eS (33.1 +/- 5.5 versus 35.3 +/- 6.1%; P < 0.05) and 10% lower mS (17.8 +/- 3.1 versus 19.7 +/- 2.7%; P < 0.001) than control subjects in the presence of significantly elevated BP, increased LVM, and more concentric LV geometry. Whereas the decreased eS was explained entirely by augmented end-systolic stress, mS remained reduced after correction for myocardial afterload. The prevalence of subclinical systolic dysfunction as defined by impaired mS was more than five-fold higher in patients with CRI compared with control subjects (24.6 versus 4.5%; P < 0.001). Systolic dysfunction was most common (48%) in patients with concentric hypertrophy and associated with lower hemoglobin levels. CRI in children is associated with impaired intrinsic LV contractility, which parallels increased LVM.
dc.language.isoeng
dc.subjectNefroloji
dc.subjectİç Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.titleReduced Systolic myocardial chronic renal insufficiency
dc.typeMakale
dc.relation.journalJOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
dc.contributor.department, ,
dc.identifier.volume18
dc.identifier.issue2
dc.identifier.startpage593
dc.identifier.endpage598
dc.contributor.firstauthorID13644


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