dc.contributor.author | Altinok, A. | |
dc.contributor.author | Kurt, A. | |
dc.contributor.author | Siva, Z. Osar | |
dc.contributor.author | Ozyazgan, Sibel | |
dc.contributor.author | Konukoglu, D. | |
dc.contributor.author | Andican, G. | |
dc.contributor.author | Karaoglu, K. | |
dc.date.accessioned | 2021-03-06T12:07:49Z | |
dc.date.available | 2021-03-06T12:07:49Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Ozyazgan S., Karaoglu K., Kurt A., Altinok A., Konukoglu D., Siva Z. O. , Andican G., "Effects of omega-3 polyunsaturated fatty acid supplementation on serum fetuin-A levels in type 2 diabetic patients", MINERVA MEDICA, cilt.104, ss.287-293, 2013 | |
dc.identifier.issn | 0026-4806 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_f26a506b-8445-465a-8e35-61cf03b1ae57 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/159009 | |
dc.description.abstract | Fetuin-A is an endogenous inhibitor of the insulin-stimulated insulin receptor tyrosine kinase recently shown that high levels of circulating fetuin-A are associated with insulin resistance in humans suggesting that fetuin-A may represent a novel mechanism involved in the pathophysiology of type 2 diabetes (T2DM). Dietary omega-3 polyunsaturated fatty acids (n-3 PUFAs) are known to reduce triglyceride levels, but their impact on glycemic control are not well known. The aim of this study to determine the effects of omega-3 PUFA supplementation on fetuin-A and glycemic control in patients with type 2 diabetes mellitus. 40 T2DM patients (17 males/23 females; aged 39-65 years) were included in the study. Serum fetuin-A levels and metabolic and biochemical profiles were measured before (baseline) and two months after n-3 PUFA supplementations (1.2 g/day). Serum fetuin-A levels were measured by enzyme-linked immunosorbent assay. Our results indicated that serum fetuin-A, fasting glucose, HbA1c and triglyceride levels were significantly decreased after supplementation (P<0.02, P<0.001, P<0.02 and P<0.01, respectively). At baseline, serum fetuin-A levels were correlated with HbA1c (r:-0.391, P<0.04). A significant positive correlation between fetuin-A and both triglycerides (r: 0.343, P<0.05) and total cholesterol (r: 0.330, P<0.05) and negative correlation between fetuin-A and fasting glucose (r: -0.405, P<0.01) were found after the supplementations. When performed multiply regression analysis, we found that serum fetuin-a levels were related with triglyceride levels (r: 0.351, P<0.01) at baseline and HbA1c levels (r: 0.344, P<0.04) after the supplementation. Based on the results, it thought that omega-3 PUFA intake decreases serum fetuin-A levels and serum fetuin-A is associated with plasma lipids and glycemic controls in type 2 diabetic patients. Further studies are required to resolve the question. | |
dc.language.iso | eng | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | TIP, GENEL & İÇECEK | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.title | Effects of omega-3 polyunsaturated fatty acid supplementation on serum fetuin-A levels in type 2 diabetic patients | |
dc.type | Makale | |
dc.relation.journal | MINERVA MEDICA | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 104 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 287 | |
dc.identifier.endpage | 293 | |
dc.contributor.firstauthorID | 33190 | |