dc.contributor.author | Dogan, R | |
dc.contributor.author | Yaylim, I | |
dc.contributor.author | Demircin, M | |
dc.contributor.author | Pasaoglu, I | |
dc.contributor.author | Isbir, CS | |
dc.date.accessioned | 2021-03-06T11:26:24Z | |
dc.date.available | 2021-03-06T11:26:24Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Isbir C., Dogan R., Demircin M., Yaylim I., Pasaoglu I., "Aprotinin reduces the IL-8 after coronary artery bypass grafting", CARDIOVASCULAR SURGERY, cilt.9, ss.403-406, 2001 | |
dc.identifier.issn | 0967-2109 | |
dc.identifier.other | av_ef04f1d6-8cda-41a7-9bdc-3a1ed54b0810 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/156891 | |
dc.identifier.uri | https://doi.org/10.1016/s0967-2109(01)00011-4 | |
dc.description.abstract | The effect of aprotinin, a protease inhibitor, on myocardial interleukin-8 (IL-8) production after ischemia-reperfusion injury was investigated. Twenty patients who had elective coronary artery bypass grafting were included in this study, Patients were randomly divided into two groups (n = 10 in each). Group A patients received high dose aprotinin (20,000 IU/kg as pretreatment followed by 7500 IU/kg for 6 h) and Group B patients received normal saline as a control. Serum IL-8 levels after the termination of cardiopulmonary bypass (CPB) showed a significant improvement in aprotinin treated group compared to control group (70+/-42.6 vs 360.71+/-87.9 ng/ml) (P<0.005). Levels were also significantly higher at post-operative 24th hour in patients who did not received aprotinin (340.16+/-92.10 vs 96.13+/-34.33 ng/ml). However at post-operative 48th hour levels were again higher in control (untreated) group, but the difference was not statistically significant (78.8+/-34.4 vs 42.8+/-9.29 ng/ml), | |
dc.language.iso | eng | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Kardiyoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | CERRAHİ | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | CARDIAC ve CARDIOVASCULAR SİSTEMLER | |
dc.title | Aprotinin reduces the IL-8 after coronary artery bypass grafting | |
dc.type | Makale | |
dc.relation.journal | CARDIOVASCULAR SURGERY | |
dc.contributor.department | , , | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 403 | |
dc.identifier.endpage | 406 | |
dc.contributor.firstauthorID | 162717 | |