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dc.contributor.authorSideli, Lucia
dc.contributor.authorAmminger, G. Paul
dc.contributor.authorPantelis, Christos
dc.contributor.authorMenezes, Paulo R.
dc.contributor.authorDel-Ben, Cristina M.
dc.contributor.authorTenan, Silvia H. Gallo
dc.contributor.authorShuhama, Rosana
dc.contributor.authorRuggeri, Mirella
dc.contributor.authorTosato, Sarah
dc.contributor.authorLasalvia, Antonio
dc.contributor.authorBonetto, Chiara
dc.contributor.authorIra, Elisa
dc.contributor.authorNordentoft, Merete
dc.contributor.authorKrebs, Marie-Odile
dc.contributor.authorBarrantes-Vidal, Neus
dc.contributor.authorCristobal, Paula
dc.contributor.authorKwapil, Thomas R.
dc.contributor.authorBrietzke, Elisa
dc.contributor.authorBressan, Rodrigo A.
dc.contributor.authorGadelha, Ary
dc.contributor.authorMaric, Nadja P.
dc.contributor.authorAndric, Sanja
dc.contributor.authorMihaljevic, Marina
dc.contributor.authorMirjanic, Tijana
dc.contributor.authorAkturan, Elin
dc.contributor.authorUcok, Alp
dc.contributor.authorSeri, Marco
dc.contributor.authorvan Os, Jim
dc.contributor.authorRutten, Bart P.
dc.contributor.authorMyin-Germeys, Inez
dc.contributor.authorDelespaul, Philippe
dc.contributor.authorViechtbauer, Wolfgang
dc.contributor.authorvan Zelst, Catherine
dc.contributor.authorBruggeman, Richard
dc.contributor.authorReininghaus, Ulrich
dc.contributor.authorMorgan, Craig
dc.contributor.authorMurray, Robin M.
dc.contributor.authorDi Forti, Marta
dc.contributor.authorMcGuire, Philip
dc.contributor.authorValmaggia, Lucia R.
dc.contributor.authorKempton, Matthew J.
dc.contributor.authorGayer-Anderson, Charlotte
dc.contributor.authorHubbard, Kathryn
dc.contributor.authorBeards, Stephanie
dc.contributor.authorStilo, Simona A.
dc.contributor.authorOnyejiaka, Adanna
dc.contributor.authorBourque, Francois
dc.contributor.authorModinos, Gemma
dc.contributor.authorTognin, Stefania
dc.contributor.authorCalem, Maria
dc.contributor.authorO'Donovan, Michael C.
dc.contributor.authorOwen, Michael J.
dc.contributor.authorHolmans, Peter
dc.contributor.authorWilliams, Nigel
dc.contributor.authorCraddock, Nicholas
dc.contributor.authorRichards, Alexander
dc.contributor.authorHumphreys, Isla
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorLeweke, F. Markus
dc.contributor.authorTost, Heike
dc.contributor.authorAkdeniz, Ceren
dc.contributor.authorRohleder, Cathrin
dc.contributor.authorBumb, J. Malte
dc.contributor.authorSchwarz, Emanuel
dc.contributor.authorALPTEKİN, KÖKSAL
dc.contributor.authorSAKA, MERAM CAN
dc.contributor.authorATBAŞOĞLU, EŞREF CEM
dc.contributor.authorGuloksuz, Sinan
dc.contributor.authorGumus-Akay, Guvem
dc.contributor.authorCihan, Burin
dc.contributor.authorKaradag, Hasan
dc.contributor.authorSoygur, Haldan
dc.contributor.authorCankurtaran, Eylem Sahin
dc.contributor.authorUlusoy, Semra
dc.contributor.authorAkdede, Berna
dc.contributor.authorBinbay, Tolga
dc.contributor.authorAyer, Ahmet
dc.contributor.authorNoyan, Handan
dc.contributor.authorKaradayi, Gulsah
dc.contributor.authorULAŞ, HALİS
dc.contributor.authorArango, Celso
dc.contributor.authorParellada, Mara
dc.contributor.authorBernardo, Miguel
dc.contributor.authorSanjuan, Julio
dc.contributor.authorBobes, Julio
dc.contributor.authorArrojo, Manuel
dc.contributor.authorLuis Santos, Jose
dc.contributor.authorCuadrado, Pedro
dc.contributor.authorRodriguez Solano, Jose Juan
dc.contributor.authorCarracedo, Angel
dc.contributor.authorGarcia Bernardo, Enrique
dc.contributor.authorRoldan, Laura
dc.contributor.authorLopez, Gonzalo
dc.contributor.authorCabrera, Bibiana
dc.contributor.authorCruz, Sabrina
dc.contributor.authorDiaz Mesa, Eva Ma
dc.contributor.authorPouso, Maria
dc.contributor.authorJimenez, Estela
dc.contributor.authorSanchez, Teresa
dc.contributor.authorRapado, Marta
dc.contributor.authorGonzalez, Emiliano
dc.contributor.authorMartinez, Covadonga
dc.contributor.authorSanchez, Emilio
dc.contributor.authorSoledad Olmeda, Ma
dc.contributor.authorde Haan, Lieuwe
dc.contributor.authorVelthorst, Eva
dc.contributor.authorvan der Gaag, Mark
dc.contributor.authorSelten, Jean-Paul
dc.contributor.authorvan Dam, Daniella
dc.contributor.authorvan der Ven, Elsje
dc.contributor.authorvan der Meer, Floor
dc.contributor.authorMesschaert, Elles
dc.contributor.authorKraan, Tamar
dc.contributor.authorBurger, Nadine
dc.contributor.authorLeboyer, Marion
dc.contributor.authorSzoke, Andrei
dc.contributor.authorSchurhoff, Franck
dc.contributor.authorLlorca, Pierre-Michel
dc.contributor.authorJamain, Stephane
dc.contributor.authorTortelli, Andrea
dc.contributor.authorFrijda, Flora
dc.contributor.authorVilain, Jeanne
dc.contributor.authorGalliot, Anne-Marie
dc.contributor.authorBaudin, Gregoire
dc.contributor.authorFerchiou, Aziz
dc.contributor.authorRichard, Jean-Romain
dc.contributor.authorBulzacka, Ewa
dc.contributor.authorCharpeaud, Thomas
dc.contributor.authorTronche, Anne-Marie
dc.contributor.authorDe Hert, Marc
dc.contributor.authorvan Winkel, Ruud
dc.contributor.authorDecoster, Jeroen
dc.contributor.authorDerom, Catherine
dc.contributor.authorThiery, Evert
dc.contributor.authorStefanis, Nikos C.
dc.contributor.authorSachs, Gabriele
dc.contributor.authorAschauer, Harald
dc.contributor.authorLasser, Iris
dc.contributor.authorWinklbaur, Bernadette
dc.contributor.authorSchlogelhofer, Monika
dc.contributor.authorRiecher-Rossler, Anita
dc.contributor.authorBorgwardt, Stefan
dc.contributor.authorWalter, Anna
dc.contributor.authorHarrisberger, Fabienne
dc.contributor.authorSmieskova, Renata
dc.contributor.authorRapp, Charlotte
dc.contributor.authorIttig, Sarah
dc.contributor.authorSoguel-Dit-Piquard, Fabienne
dc.contributor.authorStuderus, Erich
dc.contributor.authorKlosterkotter, Joachim
dc.contributor.authorRuhrmann, Stephan
dc.contributor.authorParuch, Julia
dc.contributor.authorJulkowski, Dominika
dc.contributor.authorHilboll, Desiree
dc.contributor.authorSham, Pak C.
dc.contributor.authorCherny, Stacey S.
dc.contributor.authorChen, Eric Y. H.
dc.contributor.authorCampbell, Desmond D.
dc.contributor.authorLi, Miaoxin
dc.contributor.authorMaria Romeo-Casabona, Carlos
dc.contributor.authorEmaldi Cirion, Aitziber
dc.contributor.authorUrruela Mora, Asier
dc.contributor.authorJones, Peter
dc.contributor.authorKirkbride, James
dc.contributor.authorCannon, Mary
dc.contributor.authorRujescu, Dan
dc.contributor.authorTarricone, Ilaria
dc.contributor.authorBerardi, Domenico
dc.contributor.authorBonora, Elena
dc.contributor.authorMarcacci, Thomas
dc.contributor.authorChiri, Luigi
dc.contributor.authorChierzi, Federico
dc.contributor.authorStorbini, Viviana
dc.contributor.authorBraca, Mauro
dc.contributor.authorMinenna, Maria Gabriella
dc.contributor.authorDonegani, Ivonne
dc.contributor.authorFioritti, Angelo
dc.contributor.authorLa Barbera, Daniele
dc.contributor.authorLa Cascia, Caterina Erika
dc.contributor.authorMule, Alice
dc.contributor.authorSartorio, Rachele
dc.contributor.authorFerraro, Laura
dc.contributor.authorTripoli, Giada
dc.contributor.authorSeminerio, Fabio
dc.contributor.authorMarinaro, Anna Maria
dc.contributor.authorMcGorry, Patrick
dc.contributor.authorNelson, Barnaby
dc.date.accessioned2021-03-06T11:12:53Z
dc.date.available2021-03-06T11:12:53Z
dc.date.issued2014
dc.identifier.citationvan Os J., Rutten B. P. , Myin-Germeys I., Delespaul P., Viechtbauer W., van Zelst C., Bruggeman R., Reininghaus U., Morgan C., Murray R. M. , et al., "Identifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations", SCHIZOPHRENIA BULLETIN, cilt.40, ss.729-736, 2014
dc.identifier.issn0586-7614
dc.identifier.othervv_1032021
dc.identifier.otherav_edf894b8-8926-4fe9-8b57-16bbe3faaf26
dc.identifier.urihttp://hdl.handle.net/20.500.12627/156232
dc.identifier.urihttps://doi.org/10.1093/schbul/sbu069
dc.description.abstractRecent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
dc.language.isoeng
dc.subjectPsikiyatri
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.titleIdentifying Gene-Environment Interactions in Schizophrenia: Contemporary Challenges for Integrated, Large-scale Investigations
dc.typeMakale
dc.relation.journalSCHIZOPHRENIA BULLETIN
dc.contributor.departmentUniversity of Bologna , ,
dc.identifier.volume40
dc.identifier.issue4
dc.identifier.startpage729
dc.identifier.endpage736
dc.contributor.firstauthorID215791


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