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Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism

dc.contributor.authorUysal, Mehmet Müjdat
dc.contributor.authorDogru-Abbasoglu, Semra
dc.contributor.authorMutlu-Turkoglu, U
dc.contributor.authorAYKAC-TOKER, G
dc.contributor.authorMIRSAL, H
dc.contributor.authorBEYAZYUREK, M
dc.date.accessioned2021-03-02T22:47:28Z
dc.date.available2021-03-02T22:47:28Z
dc.date.issued2000
dc.identifier.citationMutlu-Turkoglu U., Dogru-Abbasoglu S., AYKAC-TOKER G., MIRSAL H., BEYAZYUREK M., Uysal M. M. , "Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism", JOURNAL OF LABORATORY AND CLINICAL MEDICINE, cilt.136, sa.4, ss.287-291, 2000
dc.identifier.issn0022-2143
dc.identifier.otherav_0ebf9531-699e-4840-a218-56fed4203e15
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/15449
dc.identifier.urihttps://doi.org/10.1067/mlc.2000.109097
dc.description.abstractIncreased oxidative stress has been speculated to be one possible mechanism of ethanol toxicity. This study evaluates malondialdehyde (MDA) and protein carbonyl content in serum as markers of oxidative stress and DNA damage in lymphocytes in the same patients with chronic alcoholism. Patients with chronic alcoholism showed a significant increase in MDA levels and protein carbonyl content of their serum as compared with non-alcoholic control subjects. Increases in endogenous and H2O2-induced DNA damage were also observed in lymphocytes of patients with chronic alcoholism. In addition, there were significant correlations between endogenous and H2O2-induced DNA damage and serum MDA or protein carbonyl content in patients with chronic alcoholism. These results clearly indicate the presence of oxidative stress in patients with chronic alcoholism.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectTIBBİ LABORATUVAR TEKNOLOJİSİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTIP, GENEL & İÇECEK
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectTıp
dc.titleIncreased lipid and protein oxidation and DNA damage in patients with chronic alcoholism
dc.typeMakale
dc.relation.journalJOURNAL OF LABORATORY AND CLINICAL MEDICINE
dc.contributor.department, ,
dc.identifier.volume136
dc.identifier.issue4
dc.identifier.startpage287
dc.identifier.endpage291
dc.contributor.firstauthorID44848


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