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dc.contributor.authorESEN, A. Metin
dc.contributor.authorKARABULUT, Ahmet
dc.contributor.authorALBAYRAK, Sinan
dc.contributor.authorKeles, Ibrahim
dc.contributor.authorCan, Günay
dc.contributor.authorONAT, Altan
dc.contributor.authorHERGENC, Gulay
dc.contributor.authorUYAREL, Huseyin
dc.contributor.authorOZHAN, Hakan
dc.date.accessioned2021-03-06T10:20:12Z
dc.date.available2021-03-06T10:20:12Z
dc.date.issued2007
dc.identifier.citationONAT A., HERGENC G., UYAREL H., OZHAN H., ESEN A. M. , KARABULUT A., ALBAYRAK S., Can G., Keles I., "Association between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample", KIDNEY & BLOOD PRESSURE RESEARCH, cilt.30, ss.88-96, 2007
dc.identifier.issn1420-4096
dc.identifier.otherav_e9e4bc51-e2c8-4d0e-a1db-7bf0a8b128e5
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/153657
dc.identifier.urihttps://doi.org/10.1159/000100487
dc.description.abstractAims: The association of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60-89.9 ml/min/1.73 m(2)) with insulin resistance (IR) or metabolic syndrome (MS) needs be investigated in a population in which MS prevails. Methods: After excluding subjects with diabetes mellitus, 1,678 subjects from a representative cohort (median age 52 years) were studied cross sectionally. eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m(2) as limits. MS was identified using the modified criteria of the Adult Treatment Panel-III. Results: In men, whereas MS was not significantly associated with a reduced eGFR category when controlled for homeostatic model assessment (HOMA), HOMA adjusted for MS or for its components was significantly associated with the likelihood of a reduced eGFR. This likelihood was increased by 14% with a doubling of HOMA in men. Age was the dominant correlate of reduced eGFR in women, whereby an association with HOMA was not significant. Conclusion: Mildly impaired kidney function is common in nondiabetic adults among whom MS prevails, and in men it is mainly associated with IR but not with central obesity and MS-related dyslipidemia. The quadratic GFR equation enables an acceptable estimation of GFR in a general population. Copyright (c) 2007 S. Karger AG, Basel.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectFİZYOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectFizyoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectYaşam Bilimleri
dc.titleAssociation between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample
dc.typeMakale
dc.relation.journalKIDNEY & BLOOD PRESSURE RESEARCH
dc.contributor.department, ,
dc.identifier.volume30
dc.identifier.issue2
dc.identifier.startpage88
dc.identifier.endpage96
dc.contributor.firstauthorID90550


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