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Cytotoxic activity of diterpenoids isolated from Salvia hypargeia

dc.contributor.authorTopcu, G
dc.contributor.authorChai, HB
dc.contributor.authorPezzuto, JM
dc.contributor.authorUlubelen, A
dc.date.accessioned2021-03-06T10:08:51Z
dc.date.available2021-03-06T10:08:51Z
dc.date.issued1999
dc.identifier.citationUlubelen A., Topcu G., Chai H., Pezzuto J., "Cytotoxic activity of diterpenoids isolated from Salvia hypargeia", PHARMACEUTICAL BIOLOGY, cilt.37, ss.148-151, 1999
dc.identifier.issn1388-0209
dc.identifier.otherav_e8f1bee1-1ea2-4210-9865-1467b39fd6cb
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/153083
dc.identifier.urihttps://doi.org/10.1076/phbi.37.2.148.6082
dc.description.abstractTen diterpenoids [6a-hydroxysalvinolone (1), 6 alpha-hydroxytaxodone (2), aethiopinone (3), microstegiol (4). ferruginol (5), saprorthoquinone (6, 11,12-dioxoabieta-8,13-diene (7), taxodione (8), hypargenin A (9), hypargenin D (10)] and three triterpenoids [lupeol 3-acetate, delta-oleanol 3-acetate and beta-sitosterol] were isolated from the roots of Salvia hypargeia, a plant Endemic to Turkey. The crude extract and compounds 1-2, 5-10 were tested against a panel of human cancer cell lines [human breast cancer (BC 1), human lung cancer (LU 2), human colon cancer (COL 2), human epidermoidal carcinoma in mouth (KB), vinblastine-resistant ICB-VI, hormone-dependent human prostate cancer (LNCaP)] as well as P388 and ASK cells in culture. The crude extract was active in all of the rest systems, except KB. Isolates 1 and 8 were also found to mediate a generalized cytotoxic response.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectBitki Koruma
dc.subjectBİTKİ BİLİMLERİ
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTIBBİ LABORATUVAR TEKNOLOJİSİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectFitopatoloji
dc.titleCytotoxic activity of diterpenoids isolated from Salvia hypargeia
dc.typeMakale
dc.relation.journalPHARMACEUTICAL BIOLOGY
dc.contributor.department, ,
dc.identifier.volume37
dc.identifier.issue2
dc.identifier.startpage148
dc.identifier.endpage151
dc.contributor.firstauthorID123188


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