dc.contributor.author | Ocal, L | |
dc.contributor.author | Konice, M | |
dc.contributor.author | Saruhan-Direskeneli, GS | |
dc.contributor.author | Inanc, Murat | |
dc.contributor.author | Uyar, Fatma Aytül | |
dc.contributor.author | Gul, A | |
dc.contributor.author | Barrett, JH | |
dc.contributor.author | Aral, O | |
dc.date.accessioned | 2021-03-06T10:07:35Z | |
dc.date.available | 2021-03-06T10:07:35Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Gul A., Uyar F. A. , Inanc M., Ocal L., Barrett J., Aral O., Konice M., Saruhan-Direskeneli G., "A weak association of HLA-B*2702 with Behcet's disease", GENES AND IMMUNITY, cilt.3, ss.368-372, 2002 | |
dc.identifier.issn | 1466-4879 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_e8d6e6fc-eb47-44e3-8364-a2aa6af28234 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/153008 | |
dc.identifier.uri | https://doi.org/10.1038/sj.gene.6363863 | |
dc.description.abstract | This study aimed to analyse the association of HLA-B alleles other than -B51 with Behcet's disease (BD), We also investigated the frequency of HLA-B alleles sharing the same natural killer cell immunoglobulin-like receptor (KIR) binding sequence with HLA-B51. Broad-genotyping of HLA-B locus by PCR-SSOP in 174 Turkish BD patients and 191 healthy controls confirmed the strong association of B*51 with BD (60.9% in BD patients, 24.6% in healthy controls, OR=4.78). No other HLA-B allele was identified showing an association with BD after adjusting for multiple testing or by using relative predispositional effects (RPE) analysis after the deletion of B*51. HLA-B alleles reacting with the sequence specific oligonucleotide probe 23, which corresponds to the KIR binding site of B*51, were found to be positive in 127 BD patients (73%) and 90 controls (47%) (OR=3.03, 95% Cl 2-4.7). The repeated RPE analysis after separating HLA-B alleles carrying B51-KIR binding sequence as distinct alleles within a broad-type allele group revealed B*2702 allele as the only allele showing an association with BD after the deletion of B*51. Selective Increase of B*2702, the only B*27 allele carrying the same KIR binding sequence with B*51, warrants investigation of the possibility of interaction of HLA molecules with KIRs on NK or other T cells in the pathogenesis of BD. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Temel Bilimler | |
dc.subject | GENETİK VE HAYAT | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | İmmünoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Tıbbi Genetik | |
dc.title | A weak association of HLA-B*2702 with Behcet's disease | |
dc.type | Makale | |
dc.relation.journal | GENES AND IMMUNITY | |
dc.contributor.department | , , | |
dc.identifier.volume | 3 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 368 | |
dc.identifier.endpage | 372 | |
dc.contributor.firstauthorID | 165883 | |