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Mitochondrial lipid peroxides and antioxidant enzymes in the liver following phorone-induced glutathione depletion

dc.contributor.authorAlptekin, N
dc.contributor.authorUysal, M
dc.contributor.authorToker, G
dc.contributor.authorMehmetcik, G
dc.date.accessioned2021-03-06T09:58:38Z
dc.date.available2021-03-06T09:58:38Z
dc.date.issued1997
dc.identifier.citationMehmetcik G., Alptekin N., Toker G., Uysal M., "Mitochondrial lipid peroxides and antioxidant enzymes in the liver following phorone-induced glutathione depletion", RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, cilt.96, ss.353-356, 1997
dc.identifier.issn1078-0297
dc.identifier.othervv_1032021
dc.identifier.otherav_e80b7921-d12b-4d09-a1e1-9cb3f78d678c
dc.identifier.urihttp://hdl.handle.net/20.500.12627/152561
dc.description.abstractThe levels of lipid peroxidation product (malondialdehyde = MDA) vitamin C and the activities of glutathione peroxidase (GSH-Px) dismutase (SOD) were determined in the liver and its mitochondrial fraction, in the rats 2 and 18 hr after the injection of phorone, a glutathione (GSH) depleting agent. GSH levels decreased in liver homogenate and its mitochondrial fraction after 2 hr of phorone treatment, but these values returned to normal levels at 18 hr. In GSH depleted conditions, hepatic vitamin C levels increased, GSH-Px and SOD activities remained unchanged in mitochondrial and post-mitochondrial fractions. These results indicate that GSH depletion per se does not influence lipid peroxidation and GSH-Px and SOD activities in the liver and the mitochondrial fraction.
dc.language.isoeng
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleMitochondrial lipid peroxides and antioxidant enzymes in the liver following phorone-induced glutathione depletion
dc.typeMakale
dc.relation.journalRESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY
dc.contributor.department, ,
dc.identifier.volume96
dc.identifier.issue3
dc.identifier.startpage353
dc.identifier.endpage356
dc.contributor.firstauthorID119010


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