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dc.contributor.authorMelmed, S
dc.contributor.authorKadioglu, P
dc.contributor.authorPrezant, TR
dc.date.accessioned2021-03-06T09:40:35Z
dc.date.available2021-03-06T09:40:35Z
dc.date.issued1999
dc.identifier.citationPrezant T., Kadioglu P., Melmed S., "An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: Evidence for hPTTG family", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, cilt.84, ss.1149-1152, 1999
dc.identifier.issn0021-972X
dc.identifier.othervv_1032021
dc.identifier.otherav_e6a7ac36-5586-433e-9042-86890975d675
dc.identifier.urihttp://hdl.handle.net/20.500.12627/151718
dc.identifier.urihttps://doi.org/10.1210/jc.84.3.1149
dc.description.abstractA novel proto oncogene, PTTG (Pituitary Tumor Transforming Gene), was isolated in our laboratory by virtue of its increased expression in rat pituitary tumor cell lines. Cells which overexpress human or rat PTTG form tumors in athymic mice, hPTTG is highly expressed in cancer cell Lines, pituitary adenomas and in normal testis, suggesting that hPTTG protein has different tissue-specific interactions in normal cells and in cancer. Alternatively, different hPTTG gene family members may be functional in normal development and in tumorigenesis. While mapping the chromosomal location of hPTTG to 5q33, we discovered a second gene, hPTTG2, which is intronless and maps to chromosome 4p12. Using gene-specific oligonucleotide hybridization in a PCR-ELISA assay, we determined that hPTTG2 is expressed in both normal and tumorous pituitary. However, high levels of hPTTG mRNA in cancer cell lines are due to increased expression of hPTTG1. Thus, this family of proto-oncogenes appears to differentially participate in tumor-specific pathogenesis.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.titleAn intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: Evidence for hPTTG family
dc.typeMakale
dc.relation.journalJOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
dc.contributor.department, ,
dc.identifier.volume84
dc.identifier.issue3
dc.identifier.startpage1149
dc.identifier.endpage1152
dc.contributor.firstauthorID50162


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