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dc.contributor.authorYazar, Sevgi Kurt
dc.contributor.authorBayramicli, Mehmet
dc.contributor.authorHuseyinbas, Onder
dc.contributor.authorIrmak, Fatih
dc.contributor.authorSonmez, Ahmet
dc.contributor.authorSerin, Merdan
dc.contributor.authorAltinel, Dincer
dc.contributor.authorLeblebici, Cem
dc.contributor.authorBiltekin, Burcu
dc.date.accessioned2021-03-06T09:35:47Z
dc.date.available2021-03-06T09:35:47Z
dc.date.issued2019
dc.identifier.citationSerin M., Altinel D., Leblebici C., Biltekin B., Huseyinbas O., Yazar S. K. , Irmak F., Sonmez A., Bayramicli M., "Subdermal nitrous oxide delivery increases skin microcirculation and random flap survival in rats", JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, cilt.53, ss.37-44, 2019
dc.identifier.issn2000-656X
dc.identifier.otherav_e64b87cc-1bc8-49d0-a7c7-11b09ceb3661
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/151497
dc.identifier.urihttps://doi.org/10.1080/2000656x.2018.1531013
dc.description.abstractRandom skin flaps are essential tools in reconstructive surgery. In this study, we investigated the effect of subdermal nitrous oxide (N2O) application on random flap survival. In this experimental study, we used 21 female rats in three groups. In the N2O and air groups, gases were administrated under the proposed dorsal flap areas daily for seven days. Following the treatment period, flaps were raised and inserted back into their place from the dorsal skin. In the control group, the flaps were elevated and inserted back to their place without any pretreatment. Calculation of necrotic flap areas, histological examination and microangiography was performed to evaluate the results 7 days after the flap surgery. The average of necrotic flap area in the N2O, air and control group was 13.45%, 37.67% and 46.43%, respectively. (N2O vs air p = .044; N2O vs control p = .003). The average number of capillary formations identified in the histological analysis was 7.0 +/- 1.58, 3.75 +/- 2.36 and 4.4 +/- 0.54 in the N2O, air and control group, respectively. (N2O vs air p = .017; N2O vs control p = .037). The average number of capillary structures identified in the angiography images were 6.3 +/- 1.52, 1.6 +/- 1.15 and 1.3 +/- 0.57 in the N2O, air and control group, respectively. (N2O vs air p = .04; N2O vs control p = .02). We conclude that subdermal N2O application increases random flap survival through an increase in the skin microcirculation and could be promising for future clinical applications.
dc.language.isoeng
dc.subjectTıp
dc.subjectOrtopedi ve Travmatoloji
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectCERRAHİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectORTOPEDİ
dc.titleSubdermal nitrous oxide delivery increases skin microcirculation and random flap survival in rats
dc.typeMakale
dc.relation.journalJOURNAL OF PLASTIC SURGERY AND HAND SURGERY
dc.contributor.departmentIstanbul Training & Research Hospital , ,
dc.identifier.volume53
dc.identifier.issue1
dc.identifier.startpage37
dc.identifier.endpage44
dc.contributor.firstauthorID261100


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