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Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum

dc.contributor.authorTinari, Nicola
dc.contributor.authorOkyar, Alper
dc.contributor.authorLa Sorda, Rosanna
dc.contributor.authorIacobelli, Stefano
dc.contributor.authorLevi, Francis
dc.contributor.authorPiccolo, Enza
dc.contributor.authorAhowesso, Constance
dc.contributor.authorFilipski, Elisabeth
dc.contributor.authorHossard, Virginie
dc.contributor.authorGuettier, Catherine
dc.date.accessioned2021-03-06T09:24:56Z
dc.date.available2021-03-06T09:24:56Z
dc.date.issued2011
dc.identifier.citationOkyar A., Piccolo E., Ahowesso C., Filipski E., Hossard V., Guettier C., La Sorda R., Tinari N., Iacobelli S., Levi F., "Strain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum", PLOS ONE, cilt.6, 2011
dc.identifier.issn1932-6203
dc.identifier.otherav_e579947c-d722-4348-a41e-4836740f96c5
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/150971
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0020393
dc.description.abstractBackground: ATP-binding cassette transporter abcc2 is involved in the cellular efflux of irinotecan. The drug is toxic for mouse ileum, where abcc2 is highly expressed. Here, we investigate whether circadian changes in local abcc2 expression participate in the circadian rhythm of irinotecan toxicity for ileum mucosa, and further assess whether genetic background or sex modify this relation.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectDoğa Bilimleri Genel
dc.subjectTemel Bilimler (SCI)
dc.titleStrain- and Sex-Dependent Circadian Changes in Abcc2 Transporter Expression: Implications for Irinotecan Chronotolerance in Mouse Ileum
dc.typeMakale
dc.relation.journalPLOS ONE
dc.contributor.departmentCESI Univ G Annunzio , ,
dc.identifier.volume6
dc.identifier.issue6
dc.contributor.firstauthorID70401


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