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dc.contributor.authorYANG, Huan
dc.contributor.authorTuezuen, Erdem
dc.contributor.authorCHRISTADOSS, Premkumar
dc.contributor.authorUlusoy, Canan Aysel
dc.contributor.authorALLMAN, Windy
dc.date.accessioned2021-03-06T09:22:40Z
dc.date.available2021-03-06T09:22:40Z
dc.identifier.citationTuezuen E., ALLMAN W., Ulusoy C. A. , YANG H., CHRISTADOSS P., "Novel animal models of acetylcholine receptor antibody-related myasthenia gravis.", Annals of the New York Academy of Sciences, cilt.1274, ss.133-9, 2012
dc.identifier.issn0077-8923
dc.identifier.othervv_1032021
dc.identifier.otherav_e54b04ee-d4c5-4c8b-841e-590894952cc1
dc.identifier.urihttp://hdl.handle.net/20.500.12627/150845
dc.identifier.urihttps://doi.org/10.1111/j.1749-6632.2012.06773.x
dc.description.abstractExperimental autoimmune myasthenia gravis (EAMG) in mice has been used to unravel the pathogenic mechanisms and to be used as a preclinical model of myasthenia gravis (MG). Induction of predominantly ocular EAMG in HLA-DQ8 transgenic mice immunized with acetylcholine receptor (AChR) subunits demonstrated the importance of nonconformationally expressed AChR subunits in extraocular muscle involvement. Wild-type (WT) and CD4(+) T cell knockout (KO) C57BL/6 mice developed EAMG upon immunization with AChR in incomplete Freund's adjuvant plus lipopolysaccharide. AChR-specific IgG2(+) B cell frequencies, estimated by Alexa-conjugated AChR, and AChR-reactive IgG2b levels significantly correlated with the clinical grades of EAMG in WT mice. CD4(+) T cell-deficient EAMG mice exhibited AChR antibodies mainly of the IgG2b isotype, emphasizing T helper independent B cell activation pathways in EAMG induction. These novel EAMG models have suggested that diverse immunopathological mechanisms might contribute to EAMG or MG pathogenesis.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.titleNovel animal models of acetylcholine receptor antibody-related myasthenia gravis.
dc.typeMakale
dc.relation.journalAnnals of the New York Academy of Sciences
dc.contributor.departmentUniversity of Texas System , ,
dc.identifier.volume1274
dc.identifier.startpage133
dc.identifier.endpage9
dc.contributor.firstauthorID2139


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