dc.contributor.author | Dizdaroglu, F | |
dc.contributor.author | Gulluoglu, Mine | |
dc.contributor.author | Aktan, AO | |
dc.contributor.author | Yalin, R | |
dc.contributor.author | Yegen, BC | |
dc.contributor.author | Gulluoglu, B | |
dc.contributor.author | Kurtel, H | |
dc.contributor.author | Yegen, C | |
dc.date.accessioned | 2021-03-06T09:13:04Z | |
dc.date.available | 2021-03-06T09:13:04Z | |
dc.date.issued | 1999 | |
dc.identifier.citation | Gulluoglu B., Kurtel H., Gulluoglu M., Yegen C., Aktan A., Dizdaroglu F., Yalin R., Yegen B., "Role of endothelins in trinitrobenzene sulfonic acid-induced colitis in rats", DIGESTION, cilt.60, sa.5, ss.484-492, 1999 | |
dc.identifier.issn | 0012-2823 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_e49f61e9-dce7-45ad-862e-aed4ff207466 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/150433 | |
dc.identifier.uri | https://doi.org/10.1159/000007695 | |
dc.description.abstract | To determine the role of endothelins (ET) on experimental colitis, following intracolonic trinitrobenzene sulfonic acid administration, rats were given orally either bosentan (BS), a nonselective ET receptor antagonist (100 mg/kg in 5% arabic gum), or arabic gum by gavage for 2 or 14 days. Macroscopic damage scores obtained in the vehicle (1.4 +/- 0.4), acute (4.8 +/- 0.6) and chronic (3.8 +/- 0.3) colitis groups were significantly higher than in the control group (0). BS treatment reduced the scores in both acute (3 +/- 0.5) and chronic (2.3 +/- 0.5) colitis groups. Myeloperoxidase (MPO) activities of colonic tissues were elevated in acute and chronic colitis groups (325.1 +/- 44.9 and 431.8 +/- 54.6 U/g wet weight) as compared with the control group (73.6 +/- 11 U/g wet weight). Plasma protein oxidation levels were found to be significantly increased in the chronic colitis group (1,158.1 +/- 63.4 nmol/ml) compared with the control, ethanol and acute colitis groups (274.3 +/- 23.1, 490 +/- 52.2 and 422.2 +/- 50.5 nmol/ml). BS treatment significantly reduced both the protein oxidation level (375.5 +/- 46.9 nmol/ml) and MPO activity (167.5 +/- 35.8 U/g wet weight). The results of the present study suggest the involvement of ETs in the pathogenesis of colonic injury in this animal model of colitis. | |
dc.language.iso | eng | |
dc.subject | Gastroenterology | |
dc.subject | Hepatology | |
dc.subject | Health Sciences | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Gastroenteroloji-(Hepatoloji) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | GASTROENTEROLOJİ VE HEPATOLOJİ | |
dc.title | Role of endothelins in trinitrobenzene sulfonic acid-induced colitis in rats | |
dc.type | Makale | |
dc.relation.journal | DIGESTION | |
dc.contributor.department | , , | |
dc.identifier.volume | 60 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 484 | |
dc.identifier.endpage | 492 | |
dc.contributor.firstauthorID | 123908 | |