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dc.contributor.authorTunali, N. Ersoy
dc.contributor.authorPence, Sadrettin
dc.contributor.authorTiryakioglu, N. Ozan
dc.contributor.authorPence, H. H.
dc.contributor.authorTunali, H.
dc.contributor.authorOzbek, E.
dc.date.accessioned2021-03-06T09:11:14Z
dc.date.available2021-03-06T09:11:14Z
dc.date.issued2017
dc.identifier.citationPence S., Ozbek E., Tiryakioglu N. O. , Tunali N. E. , Pence H. H. , Tunali H., "rs3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer", CELLULAR AND MOLECULAR BIOLOGY, cilt.63, ss.46-52, 2017
dc.identifier.issn0145-5680
dc.identifier.othervv_1032021
dc.identifier.otherav_e472116a-3cc4-48dc-a14e-5d6f633a4a62
dc.identifier.urihttp://hdl.handle.net/20.500.12627/150325
dc.identifier.urihttps://doi.org/10.14715/cmb/2017.63.9.9
dc.description.abstractTo study the role of MMP9 and TIMP2 genotypes and expression in predisposition to bladder cancer and relation with metastasis. 100 urinary bladder cancer patients and 100 healthy controls were included in the study. rs3918242 and rs8179090 genotypes were determined with PCR-RFLP. Quantitative real-time polymerase chain reaction was employed to assess the MMP-9 and TIMP-2 expression in tumors and adjacent healthy tissues. Variant genotype (TT) for rs3918242 polymorphism and rs8179090 variant genotype are not associated with bladder cancer risk. rs3918242 genotype was significantly associated with tumor invasion. In contrast with this, rs8179090 genotype has not shown a significant association with tumor invasion. Both SNPs did not show a significant association with metastatic status. MMP-9 was upregulated in tumors in comparison to cancer free tissues. Significant increase in the expression of MMP-9 was also observed in invasive tumors. TIMP-2 expression was significantly increased in tumors in comparison to cancer free tissues and in metastatic tumors in comparison to non-metastatic tumors. Tissues with rs3918242 variant genotype have shown increased MMP-9 expression. rs3918242 promoter polymorphism of MMP-9 is significantly associated with tumor invasion, however; there is no positive correlation between TIMP-2 rs8179090 promoter polymorphism variant frequency and invasion. MMP-9 and TIMP-2 genes are upregulated in cancerous tissues when compared to normal bladder tissues.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titlers3918242 variant genotype frequency and increased TIMP-2 and MMP-9 expression are positively correlated with cancer invasion in urinary bladder cancer
dc.typeMakale
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY
dc.contributor.departmentSağlık Bilimleri Üniversitesi , ,
dc.identifier.volume63
dc.identifier.issue9
dc.identifier.startpage46
dc.identifier.endpage52
dc.contributor.firstauthorID53367


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