dc.contributor.author | Bilir, Muammer | |
dc.contributor.author | Karayel, Tunçay Mehmet | |
dc.contributor.author | Senturk, H | |
dc.contributor.author | Tabak, F | |
dc.contributor.author | Ozaras, Reşat | |
dc.contributor.author | Mert, A | |
dc.date.accessioned | 2021-03-06T09:07:09Z | |
dc.date.available | 2021-03-06T09:07:09Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Mert A., Bilir M., Ozaras R., Tabak F., Karayel T. M. , Senturk H., "Results of hepatitis B vaccination in sarcoidosis", RESPIRATION, cilt.67, ss.543-545, 2000 | |
dc.identifier.issn | 0025-7931 | |
dc.identifier.other | av_e427f34d-8007-4179-a036-9a9c2479357e | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/150134 | |
dc.identifier.uri | https://doi.org/10.1159/000067471 | |
dc.description.abstract | Background: Sarcoidosis is known to be associated with defects in cellular immunity, especially in reference to T helper lymphocytes. Anergy to a tuberculin skin test is most characteristic of this disease. Objectives: To further the data on impaired immunity, we studied the antibody response to hepatitis B vaccination in patients with sarcoidosis, Methods: Serologic markers of hepatitis B virus (HBV) (HBsAg, anti-HBs, anti-HBc) were studied in 40 patients with sarcoidosis (32 female, 8 male; mean age: 45 +/- 11 years, range: 25-66 years) with a mean duration of disease of 6 years, While a II the markers were negative in 22 patients (55%), 2 had isolated anti-HBc positivity and 16 had both anti-HBc and anti-HBs antibodies. Thirty-five age- and sex-matched healthy subjects were studied as controls, Recombinant HBV vaccines (Genhevac B Pasteur, 20 mug) were administered (at 0, 1, and 6 months) to 16 of the seronegative cases and the controls and antibody titres were measured 1 month after the last dose. The tuberculin skin test was negative in all cases. Results: While none of the vaccinees in the diseased group responded, the control group yielded an antibody response rate of 85.7% (30/35), with a mean titre of 257.9 mlU/ml. Conclusions: Patients with sarcoidosis were invariably unresponsive to standard vaccination, while some of the diseased subjects had already mounted a natural antibody response, either before or after the development of the original disease. Cellular immunodeficiency in sarcoidosis could be a suitable model for studying immunological interactions between HBV and the host. Copyright (C) 2000 S. Karger AG, Basel. | |
dc.language.iso | eng | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.title | Results of hepatitis B vaccination in sarcoidosis | |
dc.type | Makale | |
dc.relation.journal | RESPIRATION | |
dc.contributor.department | , , | |
dc.identifier.volume | 67 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 543 | |
dc.identifier.endpage | 545 | |
dc.contributor.firstauthorID | 41110 | |