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dc.contributor.authorApak, Resat
dc.contributor.authorGuclu, Kubilay
dc.contributor.authorOzyurek, Mustafa
dc.contributor.authorTufan, Ayse Nur
dc.contributor.authorCelik, Saliha Esin
dc.date.accessioned2021-03-06T08:56:08Z
dc.date.available2021-03-06T08:56:08Z
dc.date.issued2011
dc.identifier.citationCelik S. E. , Ozyurek M., Tufan A. N. , Guclu K., Apak R., "Spectroscopic study and antioxidant properties of the inclusion complexes of rosmarinic acid with natural and derivative cyclodextrins", SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, cilt.78, ss.1615-1624, 2011
dc.identifier.issn1386-1425
dc.identifier.otherav_e353770f-4f2b-438b-a178-ccba22ef9fa2
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/149599
dc.identifier.urihttps://doi.org/10.1016/j.saa.2011.02.017
dc.description.abstractMeasurement of total antioxidant activity/capacity of polyphenols in various solvent media necessitates the use of cyclodextrins to solubilize lipophilic antioxidants of poor aqueous solubility. The inclusion complexes of the slightly water soluble antioxidant, rosmarinic acid (RA), with alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), 2-hydroxyethyl-beta-cyclodextrin (HE-beta-CD), and methyl-beta-cyclodextrin (M-beta-CD) were investigated for the first time. The effect of cyclodextrins (CDs) on the spectral features of RA was measured in aqueous medium using UV-vis and steady-state fluorescence techniques by varying the concentrations of CDs. The molar stoichiometry of RA-CD inclusion complexes was verified as 1:1, and the formation constants of the complexes were determined from Benesi-Hildebrand equation using fluorescence spectroscopic data. Among the CDs, maximum inclusion ability was measured in the case of M-beta-CD followed by HP-beta-CD, HE-beta-CD, beta-CD and alpha-CD. Solid inclusion complexes were prepared by freeze drying, and their functional groups were analyzed by IR spectroscopy. Antioxidant capacity of CD-complexed rosmarinic acid was measured to be higher than that of the lone hydroxycinnamic acid by the CUPric Reducing Antioxidant Capacity (CUPRAC) method. The mechanism of the TAC increase was interpreted as the stabilization of the 1 - e oxidized o-catechol moiety of RA by enhanced intramolecular H-bonding in a hydrophobic environment provided by CDs, mostly by M-beta-CD. (C) 2011 Elsevier B.V. All rights reserved.
dc.language.isoeng
dc.subjectTemel Bilimler (SCI)
dc.subjectSpektroskopi
dc.subjectSPEKTROSKOPİ
dc.subjectKimya
dc.subjectFizikokimya
dc.subjectTemel Bilimler
dc.titleSpectroscopic study and antioxidant properties of the inclusion complexes of rosmarinic acid with natural and derivative cyclodextrins
dc.typeMakale
dc.relation.journalSPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume78
dc.identifier.issue5
dc.identifier.startpage1615
dc.identifier.endpage1624
dc.contributor.firstauthorID53077


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