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dc.contributor.authorDuranyildiz, Derya
dc.contributor.authorErturk, Kayhan
dc.contributor.authorTas, Faruk
dc.contributor.authorBilgin, Elif
dc.date.accessioned2021-03-06T08:22:45Z
dc.date.available2021-03-06T08:22:45Z
dc.date.issued2016
dc.identifier.citationTas F., Bilgin E., Erturk K., Duranyildiz D., "Clinical significance of serum claudin-1 levels in melanoma patients", MELANOMA RESEARCH, cilt.26, ss.377-381, 2016
dc.identifier.issn0960-8931
dc.identifier.otherav_e09c98bc-276b-450c-a48e-7d884d2c9bd7
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/147917
dc.identifier.urihttps://doi.org/10.1097/cmr.0000000000000241
dc.description.abstractClaudins are the most important structural and functional components of tight-junction integral membrane proteins. They play roles in major cellular functions including growth and adhesion and are responsible for regulating the paracellular transport of molecules. The objective of this study was to determine the clinical significance of the serum levels of claudin-1, an oldest and important member of the claudin family, in melanoma patients. A total of 98 patients with a pathologically confirmed melanoma were enrolled into this study. Serum claudin-1 concentrations were determined by the solid-phase sandwich enzyme-linked immunosorbent assay method. Age-matched and sex-matched 43 healthy controls were included in the analysis. The median age at diagnosis was 51 years, ranging from 16 to 85 years. The majority of the patients were male (61%) and had axial localized (54%) and metastatic disease (61%). Moreover, most of the patients with metastatic disease had M1c (73%). The baseline serum claudin-1 levels of the melanoma patients were significantly lower than those of control subjects (median values 9.17 vs. 13.82 ng/ml, respectively, P0.05). Similarly, serum claudin-1 concentration was found to have no prognostic role in survival (P=0.524). In conclusion, serum levels of claudin-1 may have a diagnostic value in melanoma patients. However, its predictive and prognostic value has not been determined. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
dc.language.isoeng
dc.subjectDermatoloji
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectReviews and References (medical)
dc.subjectResearch and Theory
dc.subjectOncology
dc.subjectDermatology
dc.subjectHealth Sciences
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectDERMATOLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.titleClinical significance of serum claudin-1 levels in melanoma patients
dc.typeMakale
dc.relation.journalMELANOMA RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume26
dc.identifier.issue4
dc.identifier.startpage377
dc.identifier.endpage381
dc.contributor.firstauthorID86076


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