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Signaling lansdscape of prostate cancer

dc.contributor.authorQadir, M. I.
dc.contributor.authorQureshi, M. Z.
dc.contributor.authorHasnain, S.
dc.contributor.authorFarooqi, A. A.
dc.contributor.authorYaylim, I.
dc.contributor.authorAttar, R.
dc.contributor.authorLin, X.
dc.contributor.authorAslam, A.
dc.date.accessioned2021-03-02T22:33:57Z
dc.date.available2021-03-02T22:33:57Z
dc.date.issued2016
dc.identifier.citationLin X., Aslam A., Attar R., Yaylim I., Qureshi M. Z. , Hasnain S., Qadir M. I. , Farooqi A. A. , "Signaling lansdscape of prostate cancer", CELLULAR AND MOLECULAR BIOLOGY, cilt.62, sa.1, ss.45-50, 2016
dc.identifier.issn0145-5680
dc.identifier.othervv_1032021
dc.identifier.otherav_0d62451f-a3f0-4875-ab71-cb405a1cb124
dc.identifier.urihttp://hdl.handle.net/20.500.12627/14610
dc.identifier.urihttps://doi.org/10.14715/cmb/2016.62.1.9
dc.description.abstractResearch over the decades has gradually and sequentially shown that both intratumor heterogeneity and multifocality make prostate cancer difficult to target. Different challenges associated with generation of risk-stratification tools that correlate genomic landscape with clinical outcomes severely influence clinical efficacy of therapeutic strategies. Androgen receptor mediated signaling has gained great appreciation and rewiring of AR induced signaling cascade in absence of androgen, structural variants of AR have provided near complete resolution of genomic landscape and underlying mechanisms of prostate cancer. In this review we have attempted to provide an overview of most recent advancements in our knowledge related to different signaling cascades including TGF, SHH, Notch, JAK-STAT in prostate cancer progression and development.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleSignaling lansdscape of prostate cancer
dc.typeMakale
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY
dc.contributor.departmentİstanbul Üniversitesi , Aziz Sancar Deneysel Tıp Araştırma Enstitüsü/Moleküler Tıp Anabilim Dalı , Moleküler Tıp Anabilim Dalı
dc.identifier.volume62
dc.identifier.issue1
dc.identifier.startpage45
dc.identifier.endpage50
dc.contributor.firstauthorID229163


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