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Synthesis and Antimicrobial Evaluation of New 3-Alkyl/aryl-2-[((alpha,alpha-diphenyl-alpha-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones

dc.contributor.authorIlhan, Eser
dc.contributor.authorSatana, Dilek
dc.contributor.authorGuzeldemirci, Nuray
dc.contributor.authorKucukbasmaci, Oemer
dc.date.accessioned2021-03-05T22:03:49Z
dc.date.available2021-03-05T22:03:49Z
dc.date.issued2010
dc.identifier.citationGuzeldemirci N., Ilhan E., Kucukbasmaci O., Satana D., "Synthesis and Antimicrobial Evaluation of New 3-Alkyl/aryl-2-[((alpha,alpha-diphenyl-alpha-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones", ARCHIVES OF PHARMACAL RESEARCH, cilt.33, ss.17-24, 2010
dc.identifier.issn0253-6269
dc.identifier.otherav_dbde9c5d-6967-4c5c-9a45-fd11fe7d2d68
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/144919
dc.identifier.urihttps://doi.org/10.1007/s12272-010-2221-y
dc.description.abstractNew 4-thiazolidinone derivatives of benzilic acid (alpha,alpha-diphenyl-alpha-hydroxyacetic acid) have been synthesized and evaluated for antibacterial and antifungal activities. The reaction of 1-(alpha,alpha-diphenyl-alpha-hydroxy)acetyl-4-alkyl/arylthiosemicarbazides with ethyl 2-bromopropionate gave 3-alkyl/aryl-2-[((alpha,alpha-diphenyl-alpha-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinone derivatives. Their antibacterial and antifungal activities were evaluated against S. aureus ATCC 29213, P. aeruginosa ATCC 27853, E. coli ATCC 25922, C. albicans ATCC 10231, C. parapsilosis ATCC 22019, C. krusei ATCC 6258, T mentagrophytes var. erinacei NCPF 375, M. gypseum NCPF 580 and T. tonsurans NCPF 245. 3e, 3f, 3g and 3h showed the highest antibacterial activity. Particularly 3a and 3e showed the highest antifungal activities against C. parapsilosis ATCC 22019, T tonsurans NCPF 245 and M. gypseum NCPF 580.
dc.language.isoeng
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleSynthesis and Antimicrobial Evaluation of New 3-Alkyl/aryl-2-[((alpha,alpha-diphenyl-alpha-hydroxy)acetyl)hydrazono]-5-methyl-4-thiazolidinones
dc.typeMakale
dc.relation.journalARCHIVES OF PHARMACAL RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume33
dc.identifier.issue1
dc.identifier.startpage17
dc.identifier.endpage24
dc.contributor.firstauthorID46826


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