dc.contributor.author | Cincin, Zeynep Birsu | |
dc.contributor.author | Cakmakoglu, Bedia | |
dc.contributor.author | KIRAN, BAYRAM | |
dc.contributor.author | Bireller, Elif Sinem | |
dc.contributor.author | BARAN, YUSUF | |
dc.contributor.author | Unlu, Miray | |
dc.date.accessioned | 2021-03-05T21:51:27Z | |
dc.date.available | 2021-03-05T21:51:27Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Cincin Z. B. , Unlu M., KIRAN B., Bireller E. S. , BARAN Y., Cakmakoglu B., "Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line", PATHOLOGY & ONCOLOGY RESEARCH, cilt.21, sa.2, ss.333-338, 2015 | |
dc.identifier.issn | 1219-4956 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_dae8e838-6363-457e-8647-05b6391cfa57 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/144285 | |
dc.identifier.uri | https://doi.org/10.1007/s12253-014-9825-3 | |
dc.description.abstract | Quercetin, which is the most abundant bioflavonoid compound, is mainly present in the glycoside form of quercitrin. Although different studies indicated that quercitrin is a potent antioxidant, the action of this compound is not well understood. In this study, we investigated whether quercitrin has apoptotic and antiproliferative effects in DLD-1 colon cancer cell lines. Time and dose dependent antiproliferative and apoptotic effects of quercitrin were subsequently determined by WST-1 cell proliferation assay, lactate dehydrogenase (LDH) cytotoxicity assay, detection of nucleosome enrichment factor, changes in caspase-3 activity, loss of mitochondrial membrane potential (MMP) and also the localization of phosphatidylserine (PS) in the plasma membrane. There were significant increases in caspase-3 activity, loss of MMP, and increases in the apoptotic cell population in response to quercitrin in DLD-1 colon cancer cells in a time- and dose-dependent manner. These results revealed that quercitrin has antiproliferative and apoptotic effects on colon cancer cells. Quercitrin activity supported with in vivo analyses could be a biomarker candicate for early colorectal carcinoma. | |
dc.language.iso | eng | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Onkoloji | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Patoloji | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.subject | PATOLOJİ | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line | |
dc.type | Makale | |
dc.relation.journal | PATHOLOGY & ONCOLOGY RESEARCH | |
dc.contributor.department | İzmir Yüksek Teknoloji Enstitüsü , , | |
dc.identifier.volume | 21 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 333 | |
dc.identifier.endpage | 338 | |
dc.contributor.firstauthorID | 221628 | |