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dc.contributor.authorGozeler, Mustafa
dc.contributor.authorDemokan, Semra
dc.contributor.authorDemir, Deniz
dc.contributor.authorDalay, Nejat
dc.contributor.authorSuoglu, Yusufhan
dc.date.accessioned2021-03-05T21:47:33Z
dc.date.available2021-03-05T21:47:33Z
dc.date.issued2010
dc.identifier.citationDemokan S., Suoglu Y., Gozeler M., Demir D., Dalay N., "N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer", MOLECULAR BIOLOGY REPORTS, cilt.37, ss.3217-3226, 2010
dc.identifier.issn0301-4851
dc.identifier.othervv_1032021
dc.identifier.otherav_da9e2ce9-ac83-46d7-a69a-86221c7d171b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/144115
dc.identifier.urihttps://doi.org/10.1007/s11033-009-9905-8
dc.description.abstractPolymorphisms that alter the function of genes involved in the activation or detoxification of carcinogenic compounds can influence an individuals risk of developing cancer. Polymorphic changes modulating the acetylation capacity of the N-acetyltransferase (NAT) genes have been implicated in the risk of developing cancer. In this study the role of genetically determined individual NAT1 and NAT2 genotypes, haplotypes and haplotype combinations in the predisposition to head and neck cancer was investigated. Polymorphic regions of the NAT1 and NAT2 genes were analyzed in patients with head and neck cancer and healthy individuals by polymerase chain reaction-restriction fragment length polymorphism. Distribution of the genotypes, allele frequencies, diplotypes and haplotypes and correlation with clinical characteristics were evaluated. No association was observed between the NAT1*3, NAT1*10, NAT1*11, NAT2*5 and NAT2*6 genotypes and risk of head and neck cancer. The NAT2*7 slow genotype was associated with reduced risk of disease. A significant association was observed between the fast acetylator NAT2*4/NAT1*10 diplotype and risk of head and neck cancer. Combined haplotypes harboring the T1088A and C1095A variants characterizing the NAT1*10 allele were associated with increased risk. Our results suggest that NAT1 and NAT2 gene combinations may influence the risk of developing head and neck cancer.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectSitogenetik
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleN-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer
dc.typeMakale
dc.relation.journalMOLECULAR BIOLOGY REPORTS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume37
dc.identifier.issue7
dc.identifier.startpage3217
dc.identifier.endpage3226
dc.contributor.firstauthorID85164


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