Comparison of early postoperative enteral nutrients versus chow on colonic anastomotic healing in normal animals

Abstract

We aimed to clarify the effects of different enteral nutrients ( normal chow, complete balanced nutrition, elemental nutrition enriched with glutamine, immune-enhancing diet and fiber) on colonic anastomotic healing in the stress-free metabolic state. The study was carried out with 50 male Balb-C mice in five groups of 10 animals each. After transverse colon anastomosis, animals were fed with early enteral nutrients using normal chow (group 1), Ensure(R) (group 2), Alitraq(R) (group 3), Impact(R) ( group 4), and Benefiber Resource(R) orange juice drink ( group 5) for 7 days. There were no significant differences among the groups in bursting pressure (p > 0.05). There was no statistical difference in terms of hydroxyproline level among groups 1 - 3. The hydroxyproline levels of groups 4 and 5 were statistically higher than that of the control group ( p < 0.05 for both comparisons). Under normal conditions without stress, we could not demonstrate the superior effects of early enteral feeding with specialized enteral preparations over normal diets on colonic anastomoses when the bursting pressures were compared. Copyright (C) 2004 S. Karger AG, Basel.