dc.contributor.author | Kirali, M | |
dc.contributor.author | Uzun, Hafize | |
dc.contributor.author | Kuscuoglu, U | |
dc.contributor.author | Akcetin, M | |
dc.contributor.author | Bilge, T | |
dc.contributor.author | Kotil, K | |
dc.date.accessioned | 2021-03-05T20:56:04Z | |
dc.date.available | 2021-03-05T20:56:04Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Kotil K., Kuscuoglu U., Kirali M., Uzun H., Akcetin M., Bilge T., "Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial", JOURNAL OF NEUROSURGERY-SPINE, cilt.4, ss.392-399, 2006 | |
dc.identifier.issn | 1547-5654 | |
dc.identifier.other | av_d68034e6-fdd8-416d-945f-5c0a01eae0f5 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/141545 | |
dc.identifier.uri | https://doi.org/10.3171/spi.2006.4.5.392 | |
dc.description.abstract | Object. No definitive treatment for spinal cord injuries (SCIs) exists, and more research is required. The use of agmatine [4-(aminobutyl)-guanidine-NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)], a guanidinium Compound formed by decarboxylation Of L-arginine by arginine decarboxylase, is a neurotransmitter-neuromodulator with both N-methyl-D-aspartate receptor (NMDAR)-antagonizing and nitric oxide synthase (NOS)-inhibiting activities. The purpose of this study was to demonstrate the dose-dependent activity of agmatine, an inducible NOS (iNOS) inhibitor and selective NMDAR antagonist, on biochemical and functional recovery in an experimental rat SCI model. | |
dc.language.iso | eng | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | Nöroloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | CERRAHİ | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | KLİNİK NEUROLOJİ | |
dc.title | Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF NEUROSURGERY-SPINE | |
dc.contributor.department | , , | |
dc.identifier.volume | 4 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 392 | |
dc.identifier.endpage | 399 | |
dc.contributor.firstauthorID | 18682 | |