dc.contributor.author | SANDRIDGE, Amy L. | |
dc.contributor.author | Bener, Abdulbari | |
dc.contributor.author | HOFFMANN, Georg F. | |
dc.contributor.author | WAHAB, Atqah Abdul | |
dc.date.accessioned | 2021-03-05T20:23:30Z | |
dc.date.available | 2021-03-05T20:23:30Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | WAHAB A. A. , Bener A., SANDRIDGE A. L. , HOFFMANN G. F. , "The pattern of Down syndrome among children in Qatar: A population-based study", BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY, cilt.76, ss.609-612, 2006 | |
dc.identifier.issn | 1542-0752 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_d3f376c4-884f-4850-9303-066244d9ed1c | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/139895 | |
dc.identifier.uri | https://doi.org/10.1002/bdra.20290 | |
dc.description.abstract | BACKGROUND:,The objective of the present study was to determine the prevalence pattern of Down Syndrome (DS) in children < 5 years of age in the State of Qatar. This is a retrospective descriptive study. The study was conducted in the Hamad General Hospital, Women's Hospital, and Rumailah Hospital (Hamad Medical Corporation). A total of 146 children were reported as having DS during the 6-year period from I January 2000 to December 31, 2005. METHODS: The diagnostic classification of definitive DS was made in accordance with criteria based on the International Classification of Disease 10th Revision (ICD-10). The data collected from the medical records included sociodemographic characteristics of the children, genetic and family history, pedigree analysis, and clinical genetic examination. RESULTS: A total of 146 children were diagnosed with DS during the last 6-year period and the prevalence rate is 19.5 per 10,000 live births. Of these, 40.4% were Qataris and 59.6% were non-Qataris. DS was slightly more common in boys (52.7%) than girls (47.3%). Infants < 1 year old had the high. est frequency of DS (40.4%), followed by children (1-2) years (26%). The most common abnormality was regular trisomy (98%). Also, one-half of the studied children had congenital heart problems (51.7%), There is a significant relationship between DS and maternal age as reported by other studies in other countries. CONCLUSION: The identification of specific types of chromosomal abnormalities in DS children is important as it enables clinicians to accurately counsel the parent regarding the recurrence risk and available options. | |
dc.language.iso | eng | |
dc.subject | Farmasötik Toksikoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Mikrobiyal Genetik | |
dc.subject | Temel Bilimler | |
dc.subject | Eczacılık | |
dc.subject | Meslek Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | TOKSİKOLOJİ | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | GELİŞİMSEL BİYOLOJİ | |
dc.title | The pattern of Down syndrome among children in Qatar: A population-based study | |
dc.type | Makale | |
dc.relation.journal | BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY | |
dc.contributor.department | , , | |
dc.identifier.volume | 76 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 609 | |
dc.identifier.endpage | 612 | |
dc.contributor.firstauthorID | 95949 | |