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dc.contributor.authorBektore, Bayhan
dc.contributor.authorUzun, Meltem
dc.contributor.authorOzyurt, Mustafa
dc.contributor.authorASLAN, GÖNÜL
dc.contributor.authorALP, ALPASLAN
dc.contributor.authorDELİALİOĞLU, NURAN
dc.contributor.authorÇOBAN, AHMET YILMAZ
dc.contributor.authorAkbal, Ahmet Ugur
dc.contributor.authorBicmen, Can
dc.contributor.authorAlbay, Ali
dc.contributor.authorSig, Ali Korhan
dc.contributor.authorSelale, Deniz Sertel
dc.contributor.authorÖZKÜTÜK, NURİ
dc.contributor.authorSÜRÜCÜOĞLU, SÜHEYLA
dc.contributor.authorAlbayrak, Nurhan
dc.contributor.authorUcarman, Nilay
dc.contributor.authorOzkutuk, Aydan
dc.contributor.authorESEN, NURAN
dc.contributor.authorCeyhan, Ismail
dc.date.accessioned2021-03-02T22:22:23Z
dc.date.available2021-03-02T22:22:23Z
dc.identifier.citationÇOBAN A. Y. , Akbal A. U. , Bicmen C., Albay A., Sig A. K. , Uzun M., Selale D. S. , ÖZKÜTÜK N., SÜRÜCÜOĞLU S., Albayrak N., et al., "Multicenter evaluation of crystal violet decolorization assay (CVDA) for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis", SCIENTIFIC REPORTS, cilt.6, 2016
dc.identifier.issn2045-2322
dc.identifier.othervv_1032021
dc.identifier.otherav_0c4bb639-8968-4eed-bdc1-0c2621c5d710
dc.identifier.urihttp://hdl.handle.net/20.500.12627/13920
dc.identifier.urihttps://doi.org/10.1038/srep39050
dc.description.abstractThe aim of this multicenter study was to evaluate the performance of the crystal violet decolorization assay (CVDA) for detection of multidrug resistant tuberculosis (MDR-TB). This study was performed in 11 centers in two phases. A total of 156 isolates were tested for INH and RIF resistance. In the phase I, 106 clinical isolates were tested in the Center 1-7. In the phase 2, 156 clinical isolates were tested in the center 1-6, center 8-11. Eighty six of 156 tested isolates were the same in phase I. Agreements were 96.2-96.8% for INH and 98.1-98.7% for RIF in the phase I-II, respectively. Mean time to obtain the results in the phase I was 14.3 +/- 5.4 days. In the phase II, mean time to obtain the results was 11.6 +/- 3.5 days. Test results were obtained within 14days for 62.3% (66/106) of isolates in the phase I and 81.4% (127/156) of isolates in the phase II. In conclusion, CVDA is rapid, reliable, inexpensive, and easy to perform for rapid detection of MDR-TB isolates. In addition, it could be adapted for drug susceptibility testing with all drugs both in developed and developing countries.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectTemel Bilimler (SCI)
dc.subjectDoğa Bilimleri Genel
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.titleMulticenter evaluation of crystal violet decolorization assay (CVDA) for rapid detection of isoniazid and rifampicin resistance in Mycobacterium tuberculosis
dc.typeMakale
dc.relation.journalSCIENTIFIC REPORTS
dc.contributor.departmentOndokuz Mayıs Üniversitesi , ,
dc.identifier.volume6
dc.contributor.firstauthorID237571


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