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dc.contributor.authorHatirnaz, Ozden
dc.contributor.authorYildiz, Inci
dc.contributor.authorErbilgin, Yücel
dc.contributor.authorDogru, Omer
dc.contributor.authorAkçay, Arzu
dc.contributor.authorSALCIOGLU, Zafer
dc.contributor.authorAYDOGAN, Gonul
dc.contributor.authorTimur, Cetin
dc.contributor.authorTUYSUZ, Gülen
dc.contributor.authorYuksel-Soycan, Lebriz
dc.contributor.authorURE, Umit
dc.contributor.authorAnak, Sema
dc.contributor.authorAgaoglu, Leyla
dc.contributor.authorDevecioglu, Omer
dc.contributor.authorOzbek, Ugur
dc.contributor.authorSayitoglu, Muge
dc.contributor.authorCelkan, Tiraje
dc.date.accessioned2021-03-05T19:45:04Z
dc.date.available2021-03-05T19:45:04Z
dc.date.issued2010
dc.identifier.citationErbilgin Y., Sayitoglu M., Hatirnaz O., Dogru O., Akçay A., TUYSUZ G., Celkan T., AYDOGAN G., SALCIOGLU Z., Timur C., et al., "Prognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL", DISEASE MARKERS, cilt.28, ss.353-360, 2010
dc.identifier.issn0278-0240
dc.identifier.othervv_1032021
dc.identifier.otherav_d0bbe626-0cf5-41ff-9afc-6fa625b04199
dc.identifier.urihttp://hdl.handle.net/20.500.12627/137974
dc.identifier.urihttps://doi.org/10.1155/2010/740140
dc.description.abstractThe NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in the majority of T- ALL patients. In this study, the mutation analysis of NOTCH1 and FBXW7 genes was performed in 87 pediatric T-ALLs who were treated on the ALL-BFM protocols. In 19 patients (22%), activating NOTCH1 mutations were observed either in the heterodimerization domain or in the PEST domain and 7 cases (10%) demonstrated FBXW7 mutations (2 cases had both NOTCH1 and FBXW7 mutations). We also analyzed the relationship of the mutation data between the clinical and biological data of the patients. NOTCH1 and FBXW7, NOTCH1 alone were found correlated with lower initial leucocyte counts which was independent from the sex and T- cell immunophenotype. However, NOTCH1 and FBXW7 mutations were not predictive of outcome in the overall cohort of pediatric T-ALLs.
dc.language.isoeng
dc.subjectBiyoloji ve Biyokimya
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGENETİK VE HAYAT
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectPATOLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.titlePrognostic significance of NOTCH1 and FBXW7 mutations in pediatric T-ALL
dc.typeMakale
dc.relation.journalDISEASE MARKERS
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume28
dc.identifier.issue6
dc.identifier.startpage353
dc.identifier.endpage360
dc.contributor.firstauthorID470


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