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dc.contributor.authorTamer, Salim
dc.contributor.authorOzkok, Elif
dc.contributor.authorAtes, G.
dc.contributor.authorBalkis, Nuray
dc.contributor.authorAksu, A.
dc.contributor.authorYorulmaz, H.
dc.contributor.authorŞahin, Onural Alper
dc.date.accessioned2021-03-05T19:11:50Z
dc.date.available2021-03-05T19:11:50Z
dc.date.issued2016
dc.identifier.citationOzkok E., Yorulmaz H., Ates G., Aksu A., Balkis N., Şahin O. A. , Tamer S., "Amelioration of Energy Metabolism by Melatonin in Skeletal Muscle of Rats With LPS Induced Endotoxemia", PHYSIOLOGICAL RESEARCH, cilt.65, ss.833-842, 2016
dc.identifier.issn0862-8408
dc.identifier.othervv_1032021
dc.identifier.otherav_ce2301f1-7931-4ea5-a2a3-c0f9942a55fc
dc.identifier.urihttp://hdl.handle.net/20.500.12627/136371
dc.identifier.urihttps://doi.org/10.33549/physiolres.933282
dc.description.abstractIn the literature, few studies have investigated the effects of melatonin on energy metabolism in skeletal muscle in endotoxemia. We investigated the effects of melatonin on tissue structure, energy metabolism in skeletal muscle, and antioxidant level of rats with endotoxemia. We divided rats into 4 groups, control, lipopolysaccharide (LPS) (20 mg/kg, i.p., single dose), melatonin (10 mg/kg, i. p., three times), and melatonin + LPS. Melatonin was injected i. p. 30 min before and after the 2nd and 4th hours of LPS injection. Antioxidant status was determined by glutathione (GSH) measurement in the blood. Muscle tissue was stained using modified Gomori trichrome (MGT), succinic dehydrogenase (SDH), and cytochrome oxidase (COX) and histological scored. Also the sections were then stained with hematoxylin and eosin. The stained sections were visualized and photographed. Creatine, creatine phosphate, adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) levels were investigated using high performance liquid chromatography (HPLC) in muscle tissue. In the Melatonin + LPS group, blood GSH levels were increased compared with the LPS group (P<0.01). Melatonin reduced myopathic changes in the LPS group according to the histopathologic findings. In addition, ATP values were increased compared with the LPS group (P<0.05). Our findings showed melatonin treatment prevented muscle damage by increasing ATP and GSH levels in rats with LPS induced endotoxemia.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectFizyoloji
dc.subjectBiyokimya
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectBiyoloji ve Biyokimya
dc.subjectFİZYOLOJİ
dc.titleAmelioration of Energy Metabolism by Melatonin in Skeletal Muscle of Rats With LPS Induced Endotoxemia
dc.typeMakale
dc.relation.journalPHYSIOLOGICAL RESEARCH
dc.contributor.departmentHaliç Üniversitesi , ,
dc.identifier.volume65
dc.identifier.issue5
dc.identifier.startpage833
dc.identifier.endpage842
dc.contributor.firstauthorID22543


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