dc.contributor.author | Cakmakoglu, Bedia | |
dc.contributor.author | Isman, Ferruh K. | |
dc.contributor.author | Dasdemir, Selcuk | |
dc.contributor.author | Seckin, Sule | |
dc.contributor.author | Kucukgergin, Canan | |
dc.contributor.author | Sanli, Oner | |
dc.date.accessioned | 2021-03-05T18:14:30Z | |
dc.date.available | 2021-03-05T18:14:30Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Isman F. K. , Kucukgergin C., Dasdemir S., Cakmakoglu B., Sanli O., Seckin S., "Association between SDF1-3 ' A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases", MOLECULAR BIOLOGY REPORTS, cilt.39, ss.11073-11079, 2012 | |
dc.identifier.issn | 0301-4851 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_c963f623-74ee-445a-834f-45c1e2c97d4e | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/133448 | |
dc.identifier.uri | https://doi.org/10.1007/s11033-012-2010-4 | |
dc.description.abstract | In the present study, we aimed to investigate the association between SDF1-3'A and CXCR4 gene polymorphisms and the susceptibility and clinicopathological development of prostate cancer. SDF1-3'A and CXCR4 gene polymorphisms were assessed by polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP) in 149 healthy subjects and 152 patients with prostate cancer. There were no significant differences in the distributions of SDF-1 and CXCR4 genotypes between controls and prostate cancer patients. However, the patients with AA genotype of SDF1-3'A gene presented a higher risk for developing an advanced disease status as compared to patients with GG homozygotes (aOR = 2.02; 95 % CI = 1.05-3.90; P = 0.035). In addition, the distribution of AA genotype of SDF1-3'A gene was found significantly increased in the patients with bone metastasis in comparison to those without bone metastasis (aOR = 2.94; 95 % CI = 1.26-6.82; P = 0.012). On the other hand, CXCR4 gene polymorphism was not associated with the clinicopathological characteristics of prostate cancer. Our results suggest that SDF1-3'A and CXCR4 gene polymorphisms may not be risk factors for the susceptibility to prostate cancer. However, SDF1-3'A gene polymorphism may be associated with the progression and bone metastasis of prostate cancer in a Turkish men population. | |
dc.language.iso | eng | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.title | Association between SDF1-3 ' A or CXCR4 gene polymorphisms with predisposition to and clinicopathological characteristics of prostate cancer with or without metastases | |
dc.type | Makale | |
dc.relation.journal | MOLECULAR BIOLOGY REPORTS | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 39 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 11073 | |
dc.identifier.endpage | 11079 | |
dc.contributor.firstauthorID | 69068 | |