dc.contributor.author | Tez, Mesut | |
dc.contributor.author | Akoglu, Musa | |
dc.contributor.author | Turhan, Nesrin | |
dc.contributor.author | Kilic, Selim | |
dc.contributor.author | Demiriz, Baris | |
dc.contributor.author | Gomceli, Ismail | |
dc.contributor.author | Bostanci, Erdal B. | |
dc.contributor.author | Ozer, Ilter | |
dc.contributor.author | Kemik, Ahu S. | |
dc.date.accessioned | 2021-03-05T18:00:19Z | |
dc.date.available | 2021-03-05T18:00:19Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Gomceli I., Bostanci E. B. , Ozer I., Kemik A. S. , Turhan N., Tez M., Kilic S., Demiriz B., Akoglu M., "A Novel Screening Biomarker in Gastric Cancer: Serum Dickkopf-1", HEPATO-GASTROENTEROLOGY, cilt.59, ss.1661-1664, 2012 | |
dc.identifier.issn | 0172-6390 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_c846daf4-1ab2-43f7-990b-bf6aa276720e | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/132727 | |
dc.identifier.uri | https://doi.org/10.5754/hge11516 | |
dc.description.abstract | Background/Aims: Despite all the knowledge about gastric cancer, there is no prognostic biomarker which could be useful for early detection. Dickkopf-1 (DKK-1), a secreted protein, is known as a negative regulator of the Wnt signaling pathway DKK-1 is reported to be over expressed in many malignant tissues. The purpose of this study was to elucidate the normal level of serum DKK-1 (sDKK-1) levels in healthy Turkish peoples and to investigate the clinical utility of sDKK-1 levels for gastric cancer screening. Methodology: Serum DKK-1 levels were measured in 69 healthy controls and in 60 gastric adenocarcinoma patients with ELISA and sDKK-1 levels were compared with clinicopathological features and outcomes in gastric cancer patients. Results: Serum concentrations of DKK-1 in gastric adeno cancer patients were significantly higher than control patients (p<0.001). The optimal cut-off for sDKK-1 levels order to discriminate control group from gastric cancer patients was 25U/mL with sensitivity equal to 100% and specificity equal to 100%. Conclusions: Serum DKK-1 levels may be a potentially useful novel serologic marker for gastric cancers. | |
dc.language.iso | eng | |
dc.subject | Gastroenteroloji-(Hepatoloji) | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | CERRAHİ | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | GASTROENTEROLOJİ VE HEPATOLOJİ | |
dc.subject | İç Hastalıkları | |
dc.title | A Novel Screening Biomarker in Gastric Cancer: Serum Dickkopf-1 | |
dc.type | Makale | |
dc.relation.journal | HEPATO-GASTROENTEROLOGY | |
dc.contributor.department | , , | |
dc.identifier.volume | 59 | |
dc.identifier.issue | 117 | |
dc.identifier.startpage | 1661 | |
dc.identifier.endpage | 1664 | |
dc.contributor.firstauthorID | 204950 | |