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dc.contributor.authorİPLİK, ELİF SİNEM
dc.contributor.authorCakmakoglu, Bedia
dc.contributor.authorCatmakas, Tolga
dc.date.accessioned2021-03-05T17:55:48Z
dc.date.available2021-03-05T17:55:48Z
dc.date.issued2018
dc.identifier.citationİPLİK E. S. , Catmakas T., Cakmakoglu B., "A new target for the treatment of endometrium cancer by succinic acid", CELLULAR AND MOLECULAR BIOLOGY, cilt.64, sa.1, ss.60-63, 2018
dc.identifier.issn0145-5680
dc.identifier.otherav_c7eb78f2-ab06-43d5-8218-68b6640b3099
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/132507
dc.identifier.urihttps://doi.org/10.14715/cmb/2018.64.1.11
dc.description.abstractEndometrium cancer is the most common invasive gynecologic malignancy in developed countries. Succinic acid (CO2HCH2-CH2CO2H) is a type of dibasic acid that has uncolored crystal. Succinic acid is used in bakery products and aromatized products. It is naturally found in some vegetables. Succinic acid has no adverse effects because it is metabolized by body cells and has a role in the tricarboxylic acid cycle (TCA) as a cycle media component. The TCA cycle and its enzyme components have some crucial roles for basal cell metabolism. Any mistakes, concentration differences in product, or enzyme deficiencies are important within the cell this cycle. In this proposal project, we aimed to investigate the effect of succinic acid at different doses and at different times in an endometrial cancer cell line. The study was performed using methods that determine for apoptosis (for cytotoxicity, WST-1, for caspase enzyme activity, Caspase 3/BCA; apoptotic determination using flow cytometry; Annexin V; to understand mitochondrial membrane potential; JC-1). The results showed that 5 and 10 mu M concentration of succinic acid resulted in apoptosis in endometrium cancer; no such effect was seen in the control cell line, which comprised healthy lung cells. According to our results, it is thought that succinic acid would be effective for the treatment of endometrial cancer cell lines, thus providing new data for other areas of cancer research.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleA new target for the treatment of endometrium cancer by succinic acid
dc.typeMakale
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY
dc.contributor.departmentİstanbul Yeni Yüzyıl Üniversitesi , Eczacılık Fakültesi , --
dc.identifier.volume64
dc.identifier.issue1
dc.identifier.startpage60
dc.identifier.endpage63
dc.contributor.firstauthorID249489


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