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dc.contributor.authorYildiz, Tulay
dc.contributor.authorCanta, Nurgul
dc.contributor.authorYusufoglu, Ayşe Sergüzel
dc.date.accessioned2021-03-05T17:41:16Z
dc.date.available2021-03-05T17:41:16Z
dc.date.issued2014
dc.identifier.citationYildiz T., Canta N., Yusufoglu A. S. , "Synthesis of new chiral keto alcohols by baker's yeast", TETRAHEDRON-ASYMMETRY, cilt.25, ss.340-347, 2014
dc.identifier.issn0957-4166
dc.identifier.otherav_c6bb987a-e206-44d9-b00c-f34d8d2c558b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/131750
dc.identifier.urihttps://doi.org/10.1016/j.tetasy.2014.01.003
dc.description.abstractFourteen chiral alpha- and beta-keto alcohols 2a-2r were synthesized by the asymmetric reduction of their corresponding diketones 1a-1r via baker's yeast. In addition, ten corresponding racemic cc-keto alcohols were synthesized by the benzoin condensation of their corresponding aldehydes, which were used for the determination of the ee values through their chiral resolution on chiral HPLC. Amongst the 15 diketones, 1j and chiral cc-keto alcohols 2i, 2j and chiral beta-keto alcohol 2r are novel compounds. Six keto alcohols 2b, 2c, 2d, 2f, 2h and 2p were synthesized by baker's yeast for the first time. There are some studies in the literature where baker's yeast was applied to the diketones 1a, 1g, 1e, 1k and 1n under various conditions different to those reported herein. The yields and the ee values of these studies were not as high as ours. All of the keto alcohols synthesized were characterized by IR, NMR (H-1 and C-13), and MS. The relationship between the structure of the diketone and the yield, diastereoselectivity and enantiomeric excess is also discussed. (C) 2014 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectKİMYA, İNORGANİK VE NÜKLEER
dc.subjectİnorganik Kimya
dc.subjectFizikokimya
dc.subjectBiyoinorganik Kimya
dc.subjectBiyokimya
dc.subjectKİMYA, FİZİKSEL
dc.subjectKİMYA, ORGANİK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectTemel Bilimler
dc.titleSynthesis of new chiral keto alcohols by baker's yeast
dc.typeMakale
dc.relation.journalTETRAHEDRON-ASYMMETRY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume25
dc.identifier.issue4
dc.identifier.startpage340
dc.identifier.endpage347
dc.contributor.firstauthorID6514


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