Evaluation of serum levels of interleukin-10, interleukin-11 and leukemia inhibitory factor in differentiation of eutopic and tubal ectopic pregnancies

Abstract

Purpose of study To investigate whether serum levels of leukemia inhibitory factor (LW). interleukin 10 (IL-10) and interleukin II (IL-11) are different in reference to the site of implantation Methods Seventeen patients with laparoscopic diagnoses of tubal ectopic pregnancy (EP) and 19 patients with intrauterine pregnancy delivering healthy term neonates (IUP) were prospectively evaluated for LIF. IL-10 and IL-11 levels The data were compared by using the Student's t-test. chi-square test. Kruskal-Wallis and the Mann-Whitney U test with Bonferroni's correction (p < 0.05) as appropriate Results A statistically significant difference was observed in serum LIF levels between the EP and IUP groups (p = 0.002). Ranges of LIF were 15-300 and 70-1200 ng/ml for the IUP and EP groups. respectively There were no significant differences between groups in terms of IL-10 and IL-11 levels Conclusion LIF but not IL-10 not IL-11. levels may be increased in early tubal ectopic pregnancies when compared to normal intrauterine pregnancies