IN VITRO ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF VARIOUS EXTRACTS OF Salvia microstegia (BOISS.) ET. BAL. FROM ANTAKYA, TURKEY

Abstract

The present study was performed to evaluate the in vitro antimicrobial and antioxidant properties of various extracts (hexane, dichloromethane, methanol/chloroform, methanol/water and direct methanol) from Salvia microstegia (Boiss.) Et. Bal., a member of Lamiaceae family. Direct methanol extracts of S. microstegia exhibited more effective antibacterial activities on the Gram-negative and Gram-positive bacteria. None of the extracts exhibited any antifungal activities on the Candida albicans ATCC 10231. The total phenolic components of S. microstegia was found 103.64 mg/g gallic acid equivalent. The antioxidant activity of the methanolic extract of S. microstegia was examined with two complementary test systems; 2,2-diphenyl-1-picrylhydrazyl (DPPH) and beta-carotene-linoleic acid assays. The 50% (IC50) inhibition activity of the methanolic extract of S. microstegia on the free radical DPPH was determined as 7.63 mg/ml. In the case of the linoleic acid system, the methanolic extract of S. microstegia showed 79.92% inhibition, this value is quite close to the value of synthetic antioxidant reagent, 92.46%.