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dc.contributor.authorNorel, Xavier
dc.contributor.authorOzen, Gulsev
dc.contributor.authorTopal, Gokce
dc.contributor.authorDogan, Birsel Sönmez
dc.contributor.authorTeskin, Onder
dc.date.accessioned2021-03-05T16:53:22Z
dc.date.available2021-03-05T16:53:22Z
dc.date.issued2016
dc.identifier.citationOzen G., Dogan B. S. , Teskin O., Norel X., Topal G., "The role of perivascular adipose tissue on human saphenous vein vascular tone", ISTANBUL JOURNAL OF PHARMACY, cilt.46, ss.1-13, 2016
dc.identifier.othervv_1032021
dc.identifier.otherav_c2c6192f-da82-4607-a8b7-b172574a1013
dc.identifier.urihttp://hdl.handle.net/20.500.12627/129272
dc.identifier.urihttp://dergipark.gov.tr/iujfp/issue/27028/284531
dc.description.abstractPerivascular adipose tissue (PVAT) is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokines that could regulate vascular tone. However, most of the studies evaluating PVAT effects on vascular tone have been performed with vessels derived from animals. Therefore, we aimed to investigate the role of PVAT surrounding human coronary bypass graft vessels such as saphenous vein (SV). Human SV preparations were set up in an organ bath in the presence or absence of their PVAT. The presence of PVAT significantly attenuated the contractile response to prostaglandin F-2 alpha (PGF(2 alpha)). However, potassium chloride (KCI)-induced concentration-response curve wasn't modified in PVAT-intact SV preparations. On the other hand, endothelium-dependent relaxation induced by acetylcholine (ACh) or endothelium-independent relaxation induced by sodium nitroprusside (SNP) were similar between SV with PVAT versus SV without PVAT preparations. Sensitivity of the SV to contractile agonists (KCI, PGF(2 alpha)) or relaxant agonists (SNP, ACh) were not modified in the presence of PVAT. These results suggest that PVAT could decrease PGF(2 alpha)-induced contractile tone via endothelium-independent mechanisms in SV. Retaining PVAT in SV preparations during bypass graft surgery could prevent graft vasospasm possibly via PVAT derived relaxant factor(s).
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleThe role of perivascular adipose tissue on human saphenous vein vascular tone
dc.typeMakale
dc.relation.journalISTANBUL JOURNAL OF PHARMACY
dc.contributor.departmentAcibadem Aile Hosp , ,
dc.identifier.volume46
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.endpage13
dc.contributor.firstauthorID228831


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