dc.contributor.author | Tezol, A | |
dc.contributor.author | Buyru, N | |
dc.contributor.author | Dalay, N | |
dc.date.accessioned | 2021-03-05T16:44:42Z | |
dc.date.available | 2021-03-05T16:44:42Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Buyru N., Tezol A., Dalay N., "p53 intronic G13964C variant in colon cancer and its association with HPV", ANTICANCER RESEARCH, cilt.25, ss.2767-2769, 2005 | |
dc.identifier.issn | 0250-7005 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_c223ecc8-d813-4e2a-8751-939377548d25 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/128836 | |
dc.description.abstract | Background: Inactivation of p53 is the most common change identified in human cancer. Nucleotide alterations in p53 intron 6 have been reported to be associated with the dysregulation of p53 function and tumor development. The aim of our study was to assess whether the intron 6 G13964C variant of the p53 gene is associated with the presence of human papillomavirus (HPV) as a risk factor in colon cancer. Materials and Methods: To determine whether the intronic G13964C alteration is involved in colon carcinogenesis, surgical specimens from 55 patients with colon cancer and HPV-positive tumors were examined by PCR-RFLP. Blood samples from 77 healthy subjects were used as the control group. Results: The 13964C variant was found in 14.5% of colon cancer patients and 12.9% of the control subjects. One patient and two controls were homozygous for this base change. Conclusion: No evidence of a significant association between the p53 G13964C allele and colon carcinoma was found. | |
dc.language.iso | eng | |
dc.subject | Onkoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | p53 intronic G13964C variant in colon cancer and its association with HPV | |
dc.type | Makale | |
dc.relation.journal | ANTICANCER RESEARCH | |
dc.contributor.department | , , | |
dc.identifier.volume | 25 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 2767 | |
dc.identifier.endpage | 2769 | |
dc.contributor.firstauthorID | 175580 | |