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dc.contributor.authorMete, O
dc.contributor.authorGulluoglu, Mine
dc.contributor.authorUysal, V
dc.contributor.authorKilicaslan, I
dc.date.accessioned2021-03-05T16:43:19Z
dc.date.available2021-03-05T16:43:19Z
dc.date.issued2005
dc.identifier.citationMete O., Kilicaslan I., Gulluoglu M., Uysal V., "Can renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis", VIRCHOWS ARCHIV, cilt.447, sa.6, ss.938-946, 2005
dc.identifier.issn0945-6317
dc.identifier.otherav_c201db0f-4ff0-44f4-af64-c12f9ca6f658
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/128751
dc.identifier.urihttps://doi.org/10.1007/s00428-005-0048-6
dc.description.abstractAmong the epithelial renal tumours with eosinophilic cytoplasm, the main differential diagnostic problem arises between renal oncocytomas (ROs) and eosinophilic variants of chromophobe renal cell carcinomas (RCCs). We investigated the possible role of anti-mitochondrial (AMA), anti-caveolin 1 (CAV1), anti-CD63 (CD63) and anti-cytokeratin 14 (CK14) antibodies in the differential diagnosis of eosinophilic epithelial tumours and applied the Muller and Mowry modification of Hale's colloidal iron stain (HCI). Thirty-five ROs and 77 eosinophilic RCCs (27 chromophobe, 28 clear cell and 22 papillary RCCs) were included in this study. Apical and/or polar CD63 immunostaining (94%) and diffuse AMA (91%) and CAV1 (88%) immunostainings were the characteristics of ROs, whereas diffuse CD63 immunostaining (96%) and diffuse-peripheral AMA (96%) and CAV1 (92%) immunostainings were characteristic immunohistochemical features of eosinophilic chromophobe RCCs. We showed CK14 antibody not to be useful in the differential diagnosis of the eosinophilic epithelial renal tumours. The staining localisations with AMA, CAV1 and CD63 antibodies were significantly different between tumour groups. AMA had 96% sensitivity and 94% specificity, whereas CAV1 had 92% sensitivity and 97% specificity in diagnosing chromophobe RCCs. With HCI staining, ROs, showing apical and/or polar staining, could be differentiated from chromophobe RCCs, showing diffuse cytoplasmic staining. HCI had fairly low (69%) sensitivity and 100% specificity, whereas CD63 had 95% sensitivity and 100% specificity to diagnose ROs. We recommend using CD63 as the best marker of choice for distinguishing ROs from eosinophilic chromophobe RCCs when standard diagnostic criteria are not helpful.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectPATOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectBiyokimya
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectTemel Bilimler
dc.subjectHistology
dc.subjectPathology and Forensic Medicine
dc.subjectBiochemistry (medical)
dc.subjectHealth Sciences
dc.titleCan renal oncocytoma be differentiated from its renal mimics? The utility of anti-mitochondrial, caveolin 1, CD63 and cytokeratin 14 antibodies in the differential diagnosis
dc.typeMakale
dc.relation.journalVIRCHOWS ARCHIV
dc.contributor.department, ,
dc.identifier.volume447
dc.identifier.issue6
dc.identifier.startpage938
dc.identifier.endpage946
dc.contributor.firstauthorID20251


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