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Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)

dc.contributor.authorTezcan, Kutluhan
dc.contributor.authorAkin, Demet
dc.contributor.authorSakalli, Eren
dc.contributor.authorAker, Rezzan Guelhan
dc.contributor.authorCarcak, Nihan
dc.contributor.authorOnat, Filiz Yilmaz
dc.date.accessioned2021-03-05T16:33:15Z
dc.date.available2021-03-05T16:33:15Z
dc.date.issued2010
dc.identifier.citationAker R. G. , Tezcan K., Carcak N., Sakalli E., Akin D., Onat F. Y. , "Localized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)", EPILEPSY RESEARCH, cilt.89, ss.7-16, 2010
dc.identifier.issn0920-1211
dc.identifier.othervv_1032021
dc.identifier.otherav_c12990c3-68fc-4d3d-b366-c6b8983d163a
dc.identifier.urihttp://hdl.handle.net/20.500.12627/128201
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2009.10.013
dc.description.abstractModels of genetic absence epilepsy are resistant to secondary generalization of focal limbic seizures. This correlates with the postnatal development of spike-and-wave discharges (SWDs), a hallmark of absence seizures arising from a cortical focus in the perioral region of somatosensory cortex. Ethosuximide injected at this site suppresses SWDs. The effect of this suppression on kindling in "Genetic Absence Epilepsy Rats from Strasbourg" (GAERS), has been compared for postnatal 30 day (PN30) rats having immature SWDs and adult (>4 months) rats having mature SWDs.
dc.language.isoeng
dc.subjectNöroloji
dc.subjectKLİNİK NEUROLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.titleLocalized cortical injections of ethosuximide suppress spike-and-wave activity and reduce the resistance to kindling in genetic absence epilepsy rats (GAERS)
dc.typeMakale
dc.relation.journalEPILEPSY RESEARCH
dc.contributor.departmentMarmara Üniversitesi , ,
dc.identifier.volume89
dc.identifier.issue1
dc.identifier.startpage7
dc.identifier.endpage16
dc.contributor.firstauthorID82322


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